In Vivo Antibodies
Functional-grade in vivo antibodies
Low- and ultra-low-endotoxin monoclonal antibodies for blocking, depletion and immune-checkpoint studies in mouse, rat and humanised models. Each in vivo antibody is formulated in PBS with no carrier protein or preservatives, alongside matched isotype controls, Fc-muted and Fc-reduced formats and VivoGenie biosimilars.
Shop in vivo antibodies by type
Ask about bulk or a cloneEndotoxin grades, isotype controls, Fc formats and popular clones
Low or ultra-low endotoxin?
Endotoxin can trigger inflammation that confounds in vivo results. Low-endotoxin antibodies suit most mouse studies. Ultra-low-endotoxin grades suit long dosing schedules, sensitive immune read-outs and germ-free or immunodeficient models. The measured endotoxin level, purity and concentration are on every datasheet.
Choosing an isotype control
Run a matched in vivo isotype control of the same host species, isotype and endotoxin grade, at the same dose, so you can separate the effect of target binding from non-specific antibody effects. The isotype is listed on each product page.
Fc-muted and Fc-reduced formats
Engineered Fc regions reduce binding to Fc receptors and complement. Use them when you want to block a target without depleting the cells that carry it, or to reduce Fc-mediated side effects in your model.
Popular clones
Bulk and custom supply
Multi-gram and long-study quantities are available on request. Contact our team for bulk pricing or a clone that isn't listed, or see our custom antibody service.