CRP Antibody (PACO01909)
- Product type:
- Host Species:
- Antibody type:
|Antibody Name:||CRP Antibody|
|Tested Applications:||ELISA, WB|
|Species Reactivity:||Human, Rat|
|Immunogen:||synthesized peptide derived from the Internal region of human CRP.|
|Storage Buffer:||Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.|
|Purification Method:||The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.|
|Synonyms:||CRP; PTX1; C-reactive protein|
|UniProt Protein Function:||Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.|
|UniProt Protein Details:|
Cofactor: Binds 2 calcium ions per subunit.
Subunit structure: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
Subcellular location: Secreted.
Tissue specificity: Found in plasma.
Induction: The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL1/interleukin-1 and IL6//interleukin-6.
Miscellaneous: This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium.
Sequence similarities: Belongs to the pentaxin family.Contains 1 pentaxin domain.
Mass spectrometry: Molecular mass is 23028 Da from positions 19 - 224. Determined by MALDI. Ref.15Molecular mass is 22930 Da from positions 19 - 223. Determined by MALDI. Ref.15
|NCBI Summary:||The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq]|
|NCBI GenInfo Identifier:||117486|
|NCBI Gene ID:||1401|
|UniProt Secondary Accession:||P02741,Q08AK3, Q8WW75, A8K078, D3DVD9, D3DVE0,|
|UniProt Related Accession:||P02741,Q5VVP7|
|Molecular Weight:||25,039 Da|
|NCBI Full Name:||C-reactive protein|
|NCBI Synonym Full Names:||C-reactive protein, pentraxin-related|
|NCBI Official Symbol:||CRP|
|NCBI Official Synonym Symbols:||PTX1; MGC88244; MGC149895|
|NCBI Protein Information:||C-reactive protein; pentraxin 1; OTTHUMP00000033307|
|UniProt Protein Name:||C-reactive protein|
|UniProt Gene Name:||CRP|
|UniProt Entry Name:||CRP_HUMAN|