ENaC alpha Antibody is a rabbit polyclonal antibody directed against ENaC alpha, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF and IP. Reported reactivity: Human, Rat, Mouse and African clawed frog (Xenopus laevis). Purified by Protein A.
The epithelial sodium channel alpha subunit (ENaCα) is a key component of the heterotrimeric ENaC complex, which regulates sodium ion transport across epithelial membranes. While traditionally studied in renal, pulmonary, and gastrointestinal systems, emerging evidence highlights ENaCα’s relevance in the central nervous system and neurodegenerative disease. ENaCα modulates ionic homeostasis and fluid balance in neural tissues, contributing to neuroprotection under stress conditions. In models of ocular hypertension, upregulation of ENaCα in retinal tissues suggests a compensatory mechanism to counteract elevated intraocular pressure, a known risk factor for glaucoma. Additionally, ENaCα expression is dynamically regulated during keratinocyte differentiation, indicating its broader role in cellular stress responses and tissue remodeling. These findings point to ENaCα as a potential modulator of neuroinflammation and glial activation—processes central to neurodegenerative pathologies such as Alzheimer’s disease and multiple sclerosis. As interest grows in ion channel dysfunction in neurodegeneration, ENaCα is gaining attention as a novel target for therapeutic intervention. Its role in maintaining ionic equilibrium and responding to mechanical and osmotic stress positions it at the intersection of neuroscience, neuroprotection, and precision medicine. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
ENaC alpha Antibody
Product SKU:
STPA00047
Size:
100 µg
Target:
ENaC alpha
Host Species:
Rabbit
Antibody Type:
Polyclonal
Research Areas:
Neuroscience, Neurotransmission, Ion Channels, Sodium Channels, Epithelial Sodium Channels (ENaC)
Buffer:
PBS, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC, ICC/IF, IP
Purification:
Protein A Purified
Concentration:
1 mg/ml
Reactivity:
Human, Rat, Mouse, African clawed frog (Xenopus laevis)
Recommended Dilution:
WB (1:1000), ICC/IF (1:400); IHC (1:25); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~85kDa.
Guarantee:
12 months from date of dispatch
Immunogen:
Produced against a synthetic peptide mapping to the N-terminal of the alpha subunit (amino acids 46-68) of rat Alpha ENaC (antibody designation 3560-2).
