ENaC beta Antibody is a rabbit polyclonal antibody directed against ENaC beta, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF and IP. Reported reactivity: Human, Mouse, Rat, African clawed frog (Xenopus laevis) and Hamster. Purified by Protein A.
The beta subunit of the epithelial sodium channel (ENaCβ) is essential for the functional assembly and regulation of the ENaC complex, which governs sodium absorption across epithelial surfaces. While ENaCβ is well-characterized in renal and pulmonary physiology, its emerging role in the nervous system is drawing increasing interest in neurodegenerative disease research. ENaCβ is critical for fluid clearance in distal lung epithelia, particularly in response to edema, and its expression is upregulated during keratinocyte differentiation—highlighting its involvement in cellular stress adaptation. In the retina, ENaCβ is differentially expressed under conditions of ocular hypertension, suggesting a role in neurovascular regulation and intraocular pressure homeostasis. These mechanisms are relevant to neurodegenerative diseases where fluid imbalance, oxidative stress, and ion dysregulation contribute to neuronal injury. Recent studies propose that ENaCβ may influence glial cell function, neuroinflammation, and blood-brain barrier integrity—key factors in the progression of disorders such as Parkinson’s disease and ALS. As a regulator of sodium flux and tissue hydration, ENaCβ represents a promising target for modulating neuroimmune responses and preserving neural function. By bridging epithelial ion transport and neural health, ENaCβ offers a novel perspective in the search for biomarkers and therapeutic strategies in neurodegeneration. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
ENaC beta Antibody
Product SKU:
STPA00048
Size:
100 µg
Target:
ENaC beta
Host Species:
Rabbit
Antibody Type:
Polyclonal
Research Areas:
Neuroscience, Neurotransmission, Ion Channels, Sodium Channels, Epithelial Sodium Channels (ENaC)
Buffer:
PBS, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC, ICC/IF, IP
Purification:
Protein A Purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse, Rat, African clawed frog (Xenopus laevis), Hamster
Recommended Dilution:
WB (1:1000), IHC (1:100); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~87kDa.
Guarantee:
12 months from date of dispatch
Immunogen:
Produced against the C-terminal tail (amino acids 617-638) of rat beta ENaC (antibody designation 3755-2)
