Anti-GRP170 Antibody [6E3-2C3]

GRP170 Antibody [6E3-2C3]

GRP170 Antibody [6E3-2C3] is a mouse monoclonal antibody directed against GRP170, offered by Assay Genie for research applications. Reported applications include WB and ICC/IF. Reported reactivity: Human, Mouse and Rat. Supplied as IgG2b, purified by Protein G.

GRP170 (also known as ORP150) is the largest member of the glucose-regulated protein (GRP) family and functions as a critical endoplasmic reticulum (ER) chaperone. It plays a central role in protein folding and secretion, particularly under conditions of cellular stress such as hypoxia. This chaperone exhibits strong cytoprotective properties by suppressing apoptosis, making it vital for cell survival in stress-prone environments like the brain. In neurodegenerative diseases—where ER stress, hypoxia, and protein misfolding are common—GRP170’s protective functions are especially relevant. Beyond its role in proteostasis, GRP170 also contributes to immune modulation. It binds to dendritic cells and delivers danger signals that can trigger anti-tumor immune responses. This dual role in cellular protection and immune activation positions GRP170 as a promising therapeutic target in both oncology and neurodegeneration. Its emerging relevance in neuroscience stems from its ability to mitigate ER stress and support neuronal viability, suggesting potential applications in diseases such as Alzheimer’s, Parkinson’s, and ALS. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.