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Anti-GRPR Antibody (CAB2940)

SKU:
CAB2940
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

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Antibody Name:Anti-GRPR Antibody
Antibody SKU:CAB2940
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 235-384 of human GRPR (NP_005305.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, SGC-7901, A-549, MCF7, Mouse brain, Mouse pancreas, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 235-384 of human GRPR (NP_005305.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KNLI QSAY NLPV EGNI HVKK QIES RKRL AKTV LVFV GLFA FCWL PNHV IYLY RSYH YSEV DTSM LHFV TSIC ARLL AFTN SCVN PFAL YLLS KSFR KQFN TQLL CCQP GLII RSHS TGRS TTCM TSLK STNP SVAT FSLI NGNI CHER YV
Gene ID:2925
Uniprot:P30550
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:43kDa
Observed MW:43kDa
Synonyms:GRPR, BB2, BB2R
Background:Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
UniProt Protein Function:GRPR: Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:bombesin receptor activity; peptide receptor activity, G-protein coupled

Biological Process: G-protein coupled receptor protein signaling pathway; cell proliferation; bombesin receptor signaling pathway; regulation of cell proliferation

NCBI Summary:Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]
UniProt Code:P30550
NCBI GenInfo Identifier:232185
NCBI Gene ID:2925
NCBI Accession:P30550.1
UniProt Secondary Accession:P30550,B2R910,
UniProt Related Accession:P30550,AAB27329
Molecular Weight:384
NCBI Full Name:Gastrin-releasing peptide receptor
NCBI Synonym Full Names:gastrin-releasing peptide receptor
NCBI Official Symbol:GRPR  
NCBI Official Synonym Symbols:BB2  
NCBI Protein Information:gastrin-releasing peptide receptor; GRP-R; bombesin receptor 2; GRP-preferring bombesin receptor
UniProt Protein Name:Gastrin-releasing peptide receptor
UniProt Synonym Protein Names:GRP-preferring bombesin receptor
Protein Family:Gastrin-releasing peptide receptor
UniProt Gene Name:GRPR  
UniProt Entry Name:GRPR_HUMAN
Anti-GRPR Antibody (CAB2940)Western blot analysis of extracts of various cell lines, using GRPR antibody (CAB2940) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.

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