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FITC Anti-Mouse CD279/PD-1 Antibody [29F.1A12] (AGEL1632)

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SKU AGEL1632
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Applications FC
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Description

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FITC Anti-Mouse CD279/PD-1 Antibody [29F.1A12]

The Mouse CD279 (PD-1) Monoclonal Antibody (FITC Conjugated) 29F.1A12 (AGEL1632) is a cutting-edge research tool designed for investigating the PD-1 protein, a key regulator of immune responses. This antibody, derived from hybridoma cells, is specifically engineered for mouse samples and is validated for use in flow cytometry applications. By binding to the PD-1 protein, it allows for precise detection and analysis in different cell types, making it an invaluable tool for studies in immunology and cancer research.PD-1, also known as programmed cell death protein 1, is a vital immune checkpoint receptor that plays a crucial role in maintaining immune balance by regulating T-cell activity.

Its involvement in immune system modulation highlights its potential as a target for exploring therapeutic interventions in cancer, infectious diseases, and autoimmune disorders. Understanding the function of PD-1 is essential for developing innovative treatments that enhance immune responses or mitigate immunosuppression in various pathological conditions.

Product Title:FITC Anti-Mouse CD279/PD-1 Antibody [29F.1A12]
SKU:AGEL1632
Size:25µg, 100µg
Clone No:29F.1A12
Synonyms:PD-1; Programmed Death-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:FITC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q02242
Gene ID:18566
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

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