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PE/Cyanine5 Anti-Mouse CD49b Antibody [DX5] (AGEL0441)

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SKU AGEL0441
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Host Species Rat
Isotype IgM
Clone DX5
Conjugation PE/Cy5
Applications FC
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Description

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PE/Cyanine5 Anti-Mouse CD49b Antibody [DX5]

The DX5 Monoclonal Antibody (AGEL0441) is a PE-Cy5 conjugated antibody designed for the detection of mouse CD49b. This antibody specifically targets the CD49b protein, which is known to be involved in cell adhesion processes and is commonly found on natural killer cells and activated T cells in mice.CD49b, also known as integrin alpha-2, plays a key role in mediating cell-cell and cell-extracellular matrix interactions. Its expression can indicate the activation status of certain immune cell populations, making it a valuable marker for immunological studies in mouse models. The DX5 Monoclonal Antibody enables precise detection and analysis of CD49b-expressing cells in various tissues and experimental settings, providing researchers with a powerful tool for investigating immune responses, inflammation, and immune cell dynamics in murine systems.

Ideal for flow cytometry and immunofluorescence applications, this antibody offers high sensitivity and specificity, allowing for accurate quantification and characterization of CD49b-positive cells. Its use can aid in understanding the role of CD49b in immune function, cell trafficking, and immune cell interactions within the complex network of the immune system. Researchers interested in dissecting the intricacies of immune responses in mouse models will find the DX5 Monoclonal Antibody an indispensable resource for their studies.

Product Title:PE/Cyanine5 Anti-Mouse CD49b Antibody [DX5]
SKU:AGEL0441
Size:50 Tests, 100 Tests, 200 Tests
Clone No:DX5
Synonyms:Integrin alpha-2;CD49 antigen-like family member B;Collagen receptor;Platelet membrane glycoprotein Ia;GPIa;VLA-2 subunit alpha;CD49b;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgM, κ
Isotype Control:PE/Cyanine5 Rat IgM, κ Isotype Control[RTK2118]
Form:Liquid
Conjugation:PE/Cyanine 5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q62469
Gene ID:16398
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:DX5 antigen has been recently characterized as CD49b. It is a 150 kD integrin α chain also known as α2 integrin, VLA-2 α chain, and integrin α2 chain. CD49b non-covalently associates with CD29 (β1 integrin) to form the CD49b/CD29 complex known as VLA-2, a receptor for collagen and laminin. CD49b is expressed on platelets, the majority of NK cells, NKT cells, and a small subset of CD8+ T cells (this population can be significantly increased following viral infection). DX5 is used for the identification and isolation of NK cells, and is especially useful for identifying NK cells in mice lacking the NK1.1 antigen.

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