nNOS Antibody [J23] is a mouse monoclonal antibody directed against nNOS, offered by Assay Genie for research applications. Reported applications include WB, ICC/IF, ELISA and IHC. Reported reactivity: Human, Mouse and Rat. Supplied as IgG2a, purified by Protein A.
Neuronal nitric oxide synthase (NOS1 or nNOS) is a constitutive enzyme responsible for producing nitric oxide (NO), a gaseous neurotransmitter involved in synaptic plasticity, neurovascular coupling, and neuroprotection. NOS1 catalyzes the oxidation of L-arginine to L-citrulline and NO, modulating intracellular signaling cascades. In neurodegenerative diseases, dysregulated NOS1 activity contributes to oxidative stress, mitochondrial dysfunction, and excitotoxicity. Excessive NO production can lead to peroxynitrite formation and protein nitration, exacerbating neuronal injury. Targeting NOS1 and its downstream pathways offers potential for therapeutic intervention in conditions such as Alzheimer’s disease, Parkinson’s disease, and ALS. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
nNOS Antibody [J23]
Product SKU:
STMA00215
Size:
100 µg
Target:
nNOS
Host Species:
Mouse
Antibody Type:
Monoclonal
Clone ID:
J23
Research Areas:
Neuroscience, Neurotransmission, Nitric Oxide, Cancer, Cancer Metabolism, Response to Hypoxia
Buffer:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, ICC/IF, ELISA, IHC
Antibody Isotype:
IgG2a
Purification:
Protein A Purified
Concentration:
1mg/ml
Reactivity:
Human, Mouse, Rat
Recommended Dilution:
WB (1:1000); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~160.97 kDa.
Guarantee:
12 months from date of dispatch
Immunogen:
Partial Human Recombinant NOS1 Protein
Immunogen Species:
Human
Accession Number:
NP_000611.1
Gene ID:
4842
Swiss-Prot:
P29475
Cellular Localization:
Cell Membrane
Tissue Specificity:
Ubiquitously expressed; detected in skeletal muscle and brain, also in testis, lung and kidney.
Alternative Names:
BNOS, Constitutive NOS, IHPS 1, IHPS1, N-NOS, NC-NOS, neuronal Nitric Oxide Synthase, Neuronal NOS, Nitric oxide synthase neuronal included, Nitric oxide synthase 1 (neuronal), Nitric oxide synthase 1, NNOS, NO, NOS 1, NOS, NOS type I, NOS-I, NOS1, NOS1_HUMAN
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