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Key Features

PE/Cyanine7 Anti-Mouse CD272 Antibody [PK18.6] (AGEL2742)

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SKU AGEL2742
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Mouse
Host Species Rat
Isotype Rat IgG1, κ
Clone PK18.6
Conjugation PE/Cyanine7
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Description

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PE/Cyanine7 Anti-Mouse CD272 Antibody [PK18.6]

The PE-Cyanine7 Anti-Mouse CD272 Antibody (PK18-6, AGEL2742) is a vital tool for researchers studying immune responses in mice. This antibody, designed for detecting CD272, a cell surface molecule involved in immune regulation, offers high specificity and sensitivity for mouse samples. By targeting the CD272 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an excellent choice for studies in immunology and related fields.CD272, also known as B and T lymphocyte attenuator (BTLA), plays a crucial role in modulating immune responses by inhibiting T-cell activation and promoting immune tolerance. Its importance in immune regulation makes it a key focus in research on autoimmune diseases, cancer immunotherapy, and other immune-related conditions.

Understanding the function of CD272 is essential for developing therapeutic strategies that can manipulate immune responses effectively in these contexts.With its validated performance in a range of applications such as flow cytometry and immunofluorescence, the PE-Cyanine7 Anti-Mouse CD272 Antibody (PK18-6, AGEL2742) is a valuable asset for scientists aiming to explore the complex interplay of immune checkpoints and develop innovative treatments for immune-related disorders in mouse models.

Product Title:PE/Cyanine7 Anti-Mouse CD272 Antibody [PK18.6]
SKU:AGEL2742
Size:50 Tests, 100 Tests, 200 Tests
Clone No:PK18.6
Synonyms:B- and T-lymphocyte attenuator;Btla;B- and T-lymphocyte-associated protein;CD272;Btla;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG1, κ
Isotype Control:PE/Cyanine7 Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q7TSA3
Gene ID:208154
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and naïve T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.

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