931 results for 'amyloid black'

Alzheimer's disease stands as a formidable challenge in the realm of neurological disorders, characterized by its progressive nature and profound impact on cognitive functions. This article delve

Quick Facts About AducanumabWhat is Aducanumab?Aducanumab is a monoclonal antibody designed to target and reduce amyloid-beta plaques in the brain, a hallmark of Alzheimer’s disease.What

Neuroscience · BiomarkersA Guide to Tau Proteins & TauopathiesTau keeps the neuronal cytoskeleton standing up. When its phosphorylation goes wrong, the same protein becomes the aggregate that defines

By Diana-Madalina Stan, PhD student, University of Salford Disease Description Alzheimer’s disease (AD), the most common cause of dementia, is a neu

Understanding the Role of APOE in Neurodegenerative DiseasesRecent findings reveal that a specific gene variant, APOE, significantly increases the risk of Alzheimer's and Parkinson's diseases, highlig

Imagine a world where we can fold the very fabric of life into microscopic machines, guiding the growth of a single neuron with the precision of a master architect. This isn't science fiction; it is

Oxidative Stress Definition Oxidative stress is a condition that results when the body produces or consumes more reactive oxygen species (ROS) than it can neutraliz

Interleukin signaling is involved in a number of biological processes, including cell growth and differentiation, inflammation and immunity. Interleukins are glycoproteins which act on hema

What are Stem Cells? Stem cells are primitive, undifferentiated, and unspecialised cells that are found in multicellular organisms

The tau protein is a hot topic in the scientific world right now. This little-known protein has been linked to Alzheimer's disease, Parkinson's disease, and other neurodegenerative disea

Neuroscience · NeuroimmunologyMicroglial Functions: Immunity, Inflammation & NeurodegenerationMicroglia are the resident immune cells of the central nervous system — dynamic sentinels that survey the

Introduction Discover the multifaceted role of CD33, a critical player in immune function and disease, shaping our approach to treating cancers and neurodegenerative conditions

Tocilizumab reverses cytokine release syndrome within hours, and it never touches the cell that started it. That sentence contains the whole mechanism. The trigger is a T cell — engaged by a CAR, a b

Antigen's are foreign molecules recognised by the immune system. Antigens can be protein, carbohydrate, lipid or nucleic acid molecules. Examples include viruses and bacteria as well as fr

Quick Facts About SiltuximabWhat is Siltuximab?Siltuximab is a monoclonal antibody targeting interleukin-6 (IL-6), a cytokine involved in inflammation and immune regulation.What is the m

What is Neuroimmunology? Neuroimmunology is a multidisciplinary scientific field dedicated to investigating the intricate and bidirectional interactions between the c

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The Brain's Sentinels: How Microglia Shape Neuroinflammation in Disease In the intricate landscape of the human brain, a silent, ever-watchful guardian stands ready to defend against injury and invas

IL-8 Overview Interleukin-8 (IL-8), also known as CXCL8, was discovered over 30 years ago as a small molecule that could promote chemotaxis and induce the production

What You Need to Know About TocilizumabWhat is Tocilizumab?Tocilizumab is a monoclonal antibody that targets the interleukin-6 (IL-6) receptor, widely used for managing autoimmune and in

The inception of induced pluripotent stem cells (iPSCs) has heralded a new dawn in the realm of biomedical research and regenerative medicine, setting the stage for groundbreaking advancements in

Key Takeaways: Microglia are immune cells in the CNS, originating from myeloid precursor cells. They surveil the CNS, respond to changes, and maintain neural health. Microglia exist in diff

Toll-Like Receptors The innate immune response has come under the spotlight in recent years due to its central role in propagating the pathogen

by Ryan Wallis, PhD student, QMUL, Blizard Institute The microscopic world of cell biology was first explored by Robert Hooke in the 17th century and published in his work, Microgra

BRIEF HISTORY OF THE “GREEN” EVOLUTION OF OXYGEN AND CARBON DIOXIDE WITHIN OUR ATMOSPHERE Million years ago carbon dioxide (CO2) levels used to be conside

Cell Death · BiomarkersCleaved Caspase-3: Activation, Function and Detection in ApoptosisCaspase-3 sits at the point where apoptotic signalling becomes irreversible. It is made as an inactive proenzym

Melanoma is an aggressive type of skin cancer that originates in melanocytes, the cells responsible for producing melanin, which gives skin its color. Although it is less common than othe

Key Points Non-alcoholic fatty liver disease (NAFLD) refe

Nod-like receptors Nod like receptors (NLRs) are a versatile family of relatively recently discovered intracellular receptors which have a br

Biomarkers · InflammationC-Reactive Protein (CRP): Structure, Function and Clinical UseCRP is the most widely measured marker of inflammation in medicine — fast to rise, fast to fall, and entirely non

Immunology · Antibody BiologyAntibody Light Chains, Heavy Chains, Constant Regions & Tumour-Associated AntigensAn antibody’s specificity comes from its variable domains and its biological effect comes

Transmission of SARS-CoV-2 (COVID-19) via Droplets and Aerosols What is COVID-19? COVID-19, the disea

The Spanish flu pandemic of 1918-1919 was the deadliest in history. It is estimated that up to 100 million people died from the virus, which is more than three times the number who d

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3D Organoid Cell Viability Assay (AKES081) effectively measures BENO model viability across different storage conditions. AKES081 detects significant viability differences, particularly

During my PhD I knew how networking was important, it helped me source reagents off other labs, get the best advice and helped me land a post doc at Cambridge University. Its not what y

Science communication (Scicomm) is currently on the up. As rebellion against the increasing distrust of science stemmed from bigoted and ignorant leaders, scientists are turning to s

Millions of people are afflicted with cancer each year. 2016 statistics for the USA alone show over half a million deaths attributed to cancer 1. We have come a long way from our early underst

Imagine a highly trained soldier, elite and effective, sent to the front lines of a relentless war. Day after day, they fight without rest, their supplies dwindle, and the enemy never stops coming. Ev

Cell Biology · PathologyNecrosis: Types, Causes, Mechanisms and How It Is MeasuredNecrosis is cell death accompanied by membrane rupture and release of intracellular contents — which is what makes it

Immunology · CytokinesIFN-gamma: Signalling, Function and Roles in Inflammation, Cancer and AutoimmunityInterferon gamma is the sole type II interferon and one of the most consequential cytokines in i