Description
Acetyl-CoA Carboxylase Polyclonal Antibody (CAB23986)
The Acetyl-CoA Carboxylase Polyclonal Antibody (ACGPAB10008) is a powerful tool for researchers studying the acetyl-CoA carboxylase enzyme, a key player in fatty acid metabolism and energy production. This antibody is produced in rabbits and has been validated for use in various applications such as Western blotting and immunohistochemistry.Acetyl-CoA carboxylase is a vital enzyme involved in the conversion of acetyl-CoA to malonyl-CoA, a precursor for fatty acid synthesis. Dysregulation of this enzyme has been linked to metabolic disorders such as obesity, diabetes, and cardiovascular diseases. By targeting the acetyl-CoA carboxylase protein, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.
The use of the Acetyl-CoA Carboxylase Polyclonal Antibody allows for the detection and analysis of this enzyme in different cell types and tissues, providing researchers with a valuable tool for investigating the role of acetyl-CoA carboxylase in health and disease. This antibody is a valuable asset for studies in biochemical research, metabolic disorders, and drug development aimed at targeting fatty acid metabolism pathways.
| Product Name: | Acetyl-CoA Carboxylase Polyclonal Antibody |
| Product Code: | CAB23986 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | 293F, HeLa |
| Cellular Location: | Cytoplasm |
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
| Immunogen: | A synthesized peptide derived from human Acetyl-CoA Carboxylase. |
| Sequence: | Email for sequence |
| Synonyms: | ACC, ACAC, ACC1, ACCA, Acac1, hACC1, ACACAD, ACCalpha, ACACalpha |
| Calculated MW: | 265kDa/276kDa |
| Observed MW: | 280kDa |
