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α-Actin-1 (ACTA1) Rabbit Monoclonal Antibody (CAB2319)

SKU:
CAB2319
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ACTA
ASMA
CFTD
CFTD1
CFTDM
MPFD
NEM1
NEM2
NEM3
SHPM
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:α-Actin-1 (ACTA1) Rabbit Monoclonal Antibody
SKU:CAB2319
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human α-Actin-1 (ACTA1) (P68133).
Sequence:MCDE DETT ALVC DNGS GLVK AGFA GDDA PRAV FPSI VGRP RHQG VMVG MGQK DSYV GDEA QSKR GILT LKYP IEHG IITN WDDM EKIW HHTF YNEL RVAP
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200
Synonyms:ACTA; ASMA; CFTD; MPFD; NEM1; NEM2; NEM3; SHPM; CFTD1; CFTDM; CMYP2A; CMYP2B; CMYP2C; α-Actin-1 (ACTA1)
Positive Sample:HeLa,A-431,RD,C6,Mouse lung,Mouse brain,Mouse heart,Rat lung,Rat heart
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, cytoskeleton.
Calculated MW:42kDa
Observed MW:42kDa

The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause a variety of myopathies, including nemaline myopathy, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects with manifestations such as hypotonia.

Purification Method:Affinity purification
Gene ID:58
Clone Number:ARC1913
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using α-Actin-1 (ACTA1) Rabbit mAb (CAB2319) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.

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