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Anti-MYH14 Antibody (CAB3690)

SKU:
CAB3690
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MYH14
DFNA4
DFNA4A
FP17425
MHC16
MYH17
NMHC II-C
NMHC-II-C
PNMHH
myosin
NMHCII-C
myosin-14
€419
Frequently bought together:

Description

Product Name:MYH14 Rabbit pAb
Product Code:CAB3690
Size:100uL
Synonyms:MYH14, DFNA4, DFNA4A, FP17425, MHC16, MYH17, NMHC II-C, NMHC-II-C, PNMHH, myosin, NMHCII-C, myosin-14
Applications:WB, IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide of human MYH14
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human
Positive Samples:A-431, HepG2, U-87MG, HT-29, 293T, A-549
Immunogen:A synthetic peptide of human MYH14
Purification Method:Affinity purification
Storage:Store at 4°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:79784
Uniprot:Q7Z406
Calculated MW:167kDa/202kDa/227kDa/228kDa/232kDa
Observed MW:245kDa
UniProt Protein Function:MYH14: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). High levels of expression are found in small intestine, colon and skeletal muscle. Expression is low in organs composed mainly of smooth muscle, such as aorta, uterus and urinary bladder. No detectable expression is found in thymus, spleen, placenta and lymphocytes. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: actomyosin; axon; brush border; cytosol; growth cone; membrane; myelin sheath; myosin II complex; stress fiber

Molecular Function:actin filament binding; actin-dependent ATPase activity; ATP binding; calmodulin binding; microfilament motor activity

Biological Process: actin filament-based movement; actomyosin structure organization and biogenesis; axon guidance; ephrin receptor signaling pathway; generation of action potential; metabolic process; regulation of cell shape; sensory perception of sound; skeletal muscle contraction; skeletal muscle development; small GTPase mediated signal transduction

Disease: Deafness, Autosomal Dominant 4a; Peripheral Neuropathy, Myopathy, Hoarseness, And Hearing Loss

NCBI Summary:This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
UniProt Code:Q7Z406
NCBI GenInfo Identifier:327478526
NCBI Gene ID:79784
NCBI Accession:Q7Z406.2
UniProt Secondary Accession:Q7Z406,Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27 Q9BW35, Q9H882, B0I1S2, C3TTN4,
UniProt Related Accession:Q7Z406
Molecular Weight:
NCBI Full Name:Myosin-14
NCBI Synonym Full Names:myosin, heavy chain 14, non-muscle
NCBI Official Symbol:MYH14  
NCBI Official Synonym Symbols:DFNA4; MHC16; MYH17; PNMHH; DFNA4A; myosin; FP17425; NMHC II-C; NMHC-II-C  
NCBI Protein Information:myosin-14
UniProt Protein Name:Myosin-14
UniProt Synonym Protein Names:Myosin heavy chain 14; Myosin heavy chain, non-muscle IIc; Non-muscle myosin heavy chain IIc; NMHC II-C
Protein Family:Myosin
UniProt Gene Name:MYH14  
UniProt Entry Name:MYH14_HUMAN

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