Description
Chicken V (D)J recombination-activating protein 2 (RAG2) ELISA Kit
The Chicken V(D)J Recombination Activating Protein 2 (RAG2) ELISA Kit is a highly sensitive and specific assay designed for the detection of RAG2 levels in chicken samples. This kit offers reliable and reproducible results, making it suitable for a variety of research applications in the field of immunology and genetics.RAG2 is a critical protein involved in the process of V(D)J recombination, which plays a crucial role in the development of the adaptive immune system in vertebrates.
Dysregulation of RAG2 function can lead to immune deficiencies and autoimmune disorders, making it an important target for study and potential therapeutic interventions.Overall, the Chicken V(D)J Recombination Activating Protein 2 (RAG2) ELISA Kit is a valuable tool for researchers looking to investigate the role of RAG2 in immune system development and function in chickens.
| Product Name: | Chicken V (D)J recombination-activating protein 2 (RAG2) ELISA Kit |
| SKU: | CHEB0351 |
| Size: | 96T |
| Target: | Chicken V (D)J recombination-activating protein 2 (RAG2) |
| Synonyms: | RAG-2 |
| Assay Type: | Sandwich |
| Detection Method: | ELISA |
| Reactivity: | Chicken |
| Detection Range: | 0.78-50ng/ml |
| Sensitivity: | 0.24ng/ml |
| Intra CV: | Provided with the Kit |
| Inter CV: | Provided with the Kit |
| Linearity: | Provided with the Kit |
| Recovery: | Provided with the Kit |
| Function: | Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. In the RAG complex, RAG2 is not the catalytic component but is required for all |