Anti-ETV7 Antibody (CAB6794)
- SKU:
- CAB6794
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-ETV7 Antibody |
| Antibody SKU: | CAB6794 |
| Antibody Size: | 20µL, 50µL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human ETV7 (NP_057219.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse skeletal muscle, Mouse liver, Rat skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human ETV7 (NP_057219.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MQEG ELAI SPIS PVAA MPPL GTHV QARC EAQI NLLG EGGI CKLP GRLR IQPA LWSR EDVL HWLR WAEQ EYSL PCTA EHGF EMNG RALC ILTK DDFR HRAP SSGD VLYE LLQY IKTQ RRAL VCGP FFGG IFRL KTPT QHSP VPPE EVTG PSQM DTRR GHLL QPPD PGLT SNFG HLDD PGLA RWTP GKEE SLNL CHCA ELGC RTQG VCSF PA |
| Gene ID: | 51513 |
| Uniprot: | Q9Y603 |
| Cellular Location: | Nucleus |
| Calculated MW: | 22kDa/29kDa/30kDa/32kDa/36kDa/38kDa |
| Observed MW: | 39kDa |
| Synonyms: | ETV7, TEL-2, TEL2, TELB |
| Background: | The protein encoded by this gene belongs to the ETS family of transcription factors, which is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes throughout development and differentiation, and are involved in oncogenesis as well. This protein is predominantly expressed in hematopoietic tissues. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene (PMID:11108721). |
| UniProt Protein Function: | ETV7: Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Isoform A does not seem to have a repressor activity. Isoform C does not seem to have a repressor activity. Belongs to the ETS family. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 6p21 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; organ morphogenesis; negative regulation of transcription from RNA polymerase II promoter; cell differentiation |
| NCBI Summary: | The protein encoded by this gene belongs to the ETS family of transcription factors, which is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes throughout development and differentiation, and are involved in oncogenesis as well. This protein is predominantly expressed in hematopoietic tissues. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene (PMID:11108721).[provided by RefSeq, May 2011] |
| UniProt Code: | Q9Y603 |
| NCBI GenInfo Identifier: | 13124589 |
| NCBI Gene ID: | 51513 |
| NCBI Accession: | Q9Y603.1 |
| UniProt Secondary Accession: | Q9Y603,Q5R3L3, Q5R3L4, Q9NZ65, Q9NZ66, Q9NZ68, Q9NZR8 Q9UNJ7, Q9Y5K4, B3KVC2, B4DVB6, B4E1G4, |
| UniProt Related Accession: | Q9Y603 |
| Molecular Weight: | 341 |
| NCBI Full Name: | Transcription factor ETV7 |
| NCBI Synonym Full Names: | ets variant 7 |
| NCBI Official Symbol: | ETV7 |
| NCBI Official Synonym Symbols: | TEL2; TELB; TEL-2 |
| NCBI Protein Information: | transcription factor ETV7; TEL2 oncogene; tel-related Ets factor; ETS-related protein Tel2; ETS translocation variant 7; Ets transcription factor TEL-2b; ets variant gene 7 (TEL2 oncogene) |
| UniProt Protein Name: | Transcription factor ETV7 |
| UniProt Synonym Protein Names: | ETS translocation variant 7; ETS-related protein Tel2; Tel-related Ets factor; Transcription factor Tel-2 |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | ETV7 |
| UniProt Entry Name: | ETV7_HUMAN |
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