Anti-GABAA Receptor Beta 3 Antibody [N87/25 (Formerly sold as S87-25)]

GABAA Receptor Beta 3 Antibody [N87/25 (Formerly sold as S87-25)]

GABAA Receptor Beta 3 Antibody [N87/25 (Formerly sold as S87-25)] is a mouse monoclonal antibody directed against GABAA Receptor Beta 3, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF and AM. Reported reactivity: Human, Mouse and Rat. Supplied as IgG1, purified by Protein G.

The GABA-A receptor beta 3 subunit (GABRB3) is a vital component of the GABA-A receptor complex, the primary class of fast-acting ligand-gated ion channels responsible for inhibitory neurotransmission in the brain. These receptors are essential for maintaining the balance between neuronal excitation and inhibition, a process critical for normal brain function and network stability. GABRB3 is widely expressed in the central nervous system and plays a key role in shaping synaptic and extrasynaptic inhibitory currents. Genetic and functional alterations in GABRB3 have been linked to a range of neurological and neurodevelopmental disorders, including epilepsy, autism spectrum disorders, and Angelman syndrome. More recently, GABRB3 has emerged as a candidate of interest in neurodegenerative disease research, where disrupted GABAergic signaling contributes to cognitive decline, synaptic dysfunction, and neuronal vulnerability. In conditions such as Alzheimer’s disease, reduced GABRB3 expression may impair inhibitory tone, leading to network hyperexcitability and excitotoxicity—hallmarks of disease progression. As a result, GABRB3 is being explored as both a biomarker and a therapeutic target for restoring inhibitory balance and protecting against neurodegeneration. Understanding the role of GABRB3 in inhibitory signaling pathways offers valuable insights into the molecular mechanisms underlying neurodegenerative diseases and supports the development of targeted interventions aimed at preserving cognitive function. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.