The GBP6 Polyclonal Antibody (PAC03714) is a valuable tool for researchers studying GBP6, a protein involved in immune regulation and host defense mechanisms. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the GBP6 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for studies in immunology and infectious disease research.GBP6, also known as guanylate binding protein 6, plays a crucial role in the innate immune response by regulating the activation of immune cells and interfering with pathogen invasion.
Its involvement in host defense mechanisms makes it a compelling target for research into infectious diseases, autoimmune disorders, and inflammation-related conditions. Investigating the function of GBP6 is essential for developing therapeutic strategies aimed at enhancing immune defenses or modulating immune responses in disease settings.
Antibody Name:
GBP6 Antibody (PACO36914)
Antibody SKU:
PACO36914
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Guanylate-binding protein 6 protein (401-600AA)
Immunohistochemistry of paraffin-embedded human lung cancer using PACO36914 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO36914 at dilution of 1:100.
Background:
Binds GTP, GDP and GMP.
Synonyms:
Guanylate-binding protein 6 (GTP-binding protein 6) (GBP-6) (Guanine nucleotide-binding protein 6), GBP6
UniProt Protein Function:
GBP6: Binds GTP, GDP and GMP. Belongs to the GBP family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: HydrolaseChromosomal Location of Human Ortholog: 1p22.2Molecular Function: GTPase activity; GTP bindingBiological Process: metabolic process; defense response to bacterium; immune response
UniProt Protein Details:
NCBI Summary:
Guanylate-binding proteins, such as GBP6, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008]
