Anti-GluR2 Antibody (CAB11316)

SKU:
CAB11316
€129 - €349

Description

Technical Manual

Anti-GluR2 Antibody

Product Name:Anti-GluR2 Antibody
Product SKU:CAB11316
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]

Immunogen:A synthesized peptide derived from human GluR2
Sequence:

Email for sequence

Gene ID:2891
Swiss Prot:P42262
Synonyms:GLUR2; GLURB; GluA2; GluR-K2; HBGR2
Calculated MW:98kDa
Observed MW:99KDa
Reactivity:Human, Mouse, Rat
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting Immunohistochemistry Immunofluorescence
Positive Samples:Mouse brain, Rat brain
Cellular Location:

Product Images

Anti-GluR2 Antibody

Western blot - GluR2 Rabbit mAb (CAB11316)

Uniprot Information

UniProt Protein Function:GluR2: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA(quisqualate) > glutamate > kainate. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing.
UniProt Protein Details:

Protein type:Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 4q32.1

Cellular Component: cell junction; endoplasmic reticulum membrane; integral to plasma membrane; plasma membrane; postsynaptic membrane

Molecular Function:alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; excitatory extracellular ligand-gated ion channel activity; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; protein binding

Biological Process: ionotropic glutamate receptor signaling pathway; signal transduction; synaptic transmission

NCBI Summary:Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P42262
NCBI GenInfo Identifier:23831146
NCBI Gene ID:2891
NCBI Accession:P42262.3
UniProt Secondary Accession:P42262,Q96FP6, A8MT92, I6L997,
UniProt Related Accession:P42262
Molecular Weight:93,775 Da
NCBI Full Name:Glutamate receptor 2
NCBI Synonym Full Names:glutamate ionotropic receptor AMPA type subunit 2
NCBI Official Symbol:GRIA2
NCBI Official Synonym Symbols:GLUR2; GLURB; GluA2; HBGR2; GluR-K2
NCBI Protein Information:glutamate receptor 2
UniProt Protein Name:Glutamate receptor 2
UniProt Synonym Protein Names:AMPA-selective glutamate receptor 2; GluR-B; GluR-K2; Glutamate receptor ionotropic, AMPA 2; GluA2
Protein Family:Glutamate receptor
UniProt Gene Name:GRIA2
UniProt Entry Name:GRIA2_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Signal Transduction
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