Anti-GLUT1 Antibody (CAB11727)

SKU:
CAB11727
€129 - €349

Description

Technical Manual

Anti-GLUT1 Antibody

Product Name:Anti-GLUT1 Antibody
Product SKU:CAB11727
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia. [provided by RefSeq, Apr 2013]

Immunogen:A synthesized peptide derived from human GLUT1
Sequence:

Email for sequence

Gene ID:6513
Swiss Prot:P11166
Synonyms:CSE; DYT17; DYT18; DYT9; EIG12; GLUT; GLUT-1; GLUT1; GLUT1DS; HTLVR; PED; SDCHCN
Calculated MW:54kDa
Observed MW:45kd
Reactivity:Human, Mouse, Rat
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting
Positive Samples:SH-SY5Y, K-562, Mouse brain
Cellular Location:

Product Images

Anti-GLUT1 Antibody

Western blot - GLUT1 Rabbit mAb (CAB11727)

Uniprot Information

UniProt Protein Function:GLUT1: an integral membrane protein that plays an important role in the glycolytic pathway by serving as a uniporter for glucose. One of 13 members of the human equilibrative glucose transport protein family. Transports a wide range of aldoses, including both pentoses and hexoses, and dehydroascorbic acid. Shown to transport water against an osmotic gradient. A receptor for the Human T-cell Leukemia virus (HTLV). Plays a role in the constitutive or basal uptake of glucose. Expressed at highest levels in proliferating cells of the early developing embryo, cells forming the blood tissue barriers, in human erythrocytes, astrocytes and in cardiac muscle. GLUT1 and GLUT3 are both essential for normal embryonic development. Is practically the only member of the GLUT family expressed on human red blood cells, where it comprises 10 - 20% of the integral membrane protein content. Several glycolytic proteins including the transporters GLUT1 and GLUT3, as well as multiple enzymes including HK2, PFKL, LDHA, ALDOA, ALDOC, PGK1, ENO1, PKM2, CA9 and PFKFB3 are induced in cancer cells by HIF-1 alpha. Polyps from Peutz-Jeghers patients exhibit up-regulated mTORC1 signaling, HIF-1alpha, and GLUT1 levels. Defects in GLUT1 are the cause of autosomal dominant GLUT1 deficiency syndrome, a blood-brain barrier glucose transport defect characterized by infantile seizures, delayed development, and acquired microcephaly. Defects also cause dystonia type 18, an exercise-induced paroxysmal dystonia/dyskinesia. Cytochalasin B binds to its inner surface, inhibiting its glucose transport activity with an IC50 of 0.44 uM.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 1p34.2

Cellular Component: cortical actin cytoskeleton; Golgi membrane; integral to plasma membrane; membrane; midbody; plasma membrane

Molecular Function:D-glucose transmembrane transporter activity; dehydroascorbic acid transporter activity; glucose transmembrane transporter activity; identical protein binding; protein binding; protein self-association

Biological Process: glucose transport; L-ascorbic acid metabolic process; lactose biosynthetic process; protein complex assembly; regulation of insulin secretion

Disease: Stomatin-deficient Cryohydrocytosis With Neurologic Defects

NCBI Summary:This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia. [provided by RefSeq, Apr 2013]
UniProt Code:P11166
NCBI GenInfo Identifier:115502394
NCBI Gene ID:6513
NCBI Accession:P11166.2
UniProt Secondary Accession:P11166,O75535, Q147X2, A8K9S6, B2R620, D3DPX0,
UniProt Related Accession:P11166
Molecular Weight:54,084 Da
NCBI Full Name:Solute carrier family 2, facilitated glucose transporter member 1
NCBI Synonym Full Names:solute carrier family 2 member 1
NCBI Official Symbol:SLC2A1
NCBI Official Synonym Symbols:CSE; PED; DYT9; GLUT; DYT17; DYT18; EIG12; GLUT1; HTLVR; GLUT-1; SDCHCN; GLUT1DS
NCBI Protein Information:solute carrier family 2, facilitated glucose transporter member 1
UniProt Protein Name:Solute carrier family 2, facilitated glucose transporter member 1
UniProt Synonym Protein Names:Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporter
Protein Family:Glucose transporter
UniProt Gene Name:SLC2A1
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Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Signal Transduction
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