Recombinant Human CD160 Protein(His Tag) (RPES5970)
CD16 antigen, also known as Natural killer cell receptor BY55 and CD16, is a cell membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. CD16 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic CD56(dim)CD16(+) peripheral blood NK subset. CD16 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules. CD16 is expressed in spleen, peripheral blood, and small intestine. Expression of CD16 is restricted to functional NK and T cytotoxic lymphocytes. CD16 acts as a co-activator receptor for CD3-induced proliferation of CD4+ CD16+ T cells isolated from inflammatory skin lesions. Unique CD4+ CD16+ lymphocyte subset may play a role in the pathogenesis of skin inflammation. Activated NK lymphocytes release a soluble form of CD16 that functionally impairs the MHC-I-specific cytotoxic CD8(+) T lymphocyte responsiveness.
Product Name:
Recombinant Human CD160 Protein(His Tag)
SKU:
RPES5970
Size:
100μg, 20μg, 500μg, 1mg
Species:
Human
Synonyms:
Natural killer cell receptor BY55
Tag:
C-His
Sequence:
Met1-Leu158
Expression Host:
HEK293 Cells
Accession:
O95971
Endotoxin:
< 1.0 EU/mg of the protein as determined by the LAL method
Purity:
> 90% as determined by reducing SDS-PAGE.
Calculated MW:
14.9 kDa
Observed MW:
25 kDa
Bio-Activity:
Not validated for activity
Form:
Lyophilized powder
Source:
HEK293 Cells-derived Human CD160 protein Met1-Leu158, with an C-terminal His
Formulation:
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Reconstitution:
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Storage:
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to - 80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
