Human STAT3 Recombinant Protein (hFc Tag) (HDPT0404)

SKU:
HDPT0404
Product Type:
Recombinant Protein
Host Species:
HEK293
Reactivity:
Human
€550

Description

Human STAT3 Recombinant Protein (hFc Tag)

Description:The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
Product name:Human STAT3 Recombinant Protein (hFc Tag)
Synonyms:ADMIO; ADMIO1; APRF; HIES
Type:protein
Size:50 µg
Name:STAT3
Origin:Human
Source:HEK293
Protein Type:Recombinant
Application:Contact Technical Support
Purity:Contact Technical Support
Purification:affinity purification
Format:Lyophilized
Conjugate:C-Human Fc
Storage:Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage:Research use only
Buffer:Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Reconstitution:Reconstitute with deionized water
Sequence:STAT3 (Ala2-Met770)+hFc (Glu99-Ala330)
Gene ID:
Uniprot:P40763
Molecular Weight:110.11 kDa
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