Human TERT Recombinant Protein (hFc Tag) (HDPT0406)

SKU:
HDPT0406
Product Type:
Recombinant Protein
Host Species:
HEK293
Reactivity:
Human
€550

Description

Human TERT Recombinant Protein (hFc Tag)

Description:Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]
Product name:Human TERT Recombinant Protein (hFc Tag)
Synonyms:CMM9; DKCA2; DKCB4; EST2; hEST2; hTRT; PFBMFT1; TCS1; TP2; TRT
Type:protein
Size:50 µg
Name:TERT
Origin:Human
Source:HEK293
Protein Type:Recombinant
Application:Contact Technical Support
Purity:Contact Technical Support
Purification:affinity purification
Format:Lyophilized
Conjugate:C-Human Fc
Storage:Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage:Research use only
Buffer:Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Reconstitution:Reconstitute with deionized water
Sequence:TERT (Met1-Asp1132)+hFc (Glu99-Ala330)
Gene ID:
Uniprot:O14746
Molecular Weight:150.04 kDa
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