The KDELr3 Polyclonal Antibody (PACO02386) is a valuable tool for researchers studying endoplasmic reticulum (ER) proteins and their functions. This antibody, raised in rabbits, is highly specific for KDELr3 and is validated for use in multiple applications, including Western blot and immunofluorescence.KDELr3, also known as ER protein 47, is a key player in protein trafficking and quality control within the ER. It is involved in the retrieval of ER resident proteins, ensuring proper protein folding and preventing ER stress.
Aberrant expression or dysfunction of KDELr3 has been implicated in various diseases, including neurodegenerative disorders and cancer.By using the KDELr3 Polyclonal Antibody, researchers can study the expression levels and subcellular localization of KDELr3 in different cell types and conditions. This can provide valuable insights into the role of KDELr3 in ER homeostasis and disease pathogenesis, ultimately paving the way for the development of targeted therapies.
Antibody Name:
KDELR3 Antibody
Antibody SKU:
PACO02386
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human KDEL Receptor 3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
KDELR3; ER lumen protein retaining receptor 3; KDEL endoplasmic reticulum protein retention receptor 3; KDEL receptor 3
UniProt Protein Function:
Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L ().
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the KDEL endoplasmic reticulum protein retention receptor family. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
