The BRD4-S Polyclonal Antibody (CAB20019) is a valuable tool for researchers studying BRD4-S, a protein involved in regulating gene expression and chromatin remodeling. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to BRD4-S, this antibody allows for the detection and analysis of the protein in a variety of cell types, making it essential for studies in fields like epigenetics, cancer research, and drug development.
BRD4-S is a key player in cellular processes such as transcriptional regulation and cell growth, making it a significant target for research into diseases like cancer and inflammatory disorders. Understanding the functions and mechanisms of BRD4-S can provide valuable insights into the development of targeted therapies and treatments. The validation and specificity of the BRD4-S Polyclonal Antibody make it an essential tool for researchers looking to delve deeper into the role of BRD4-S in various biological processes.
Product Name:
[KO Validated] BRD4 Rabbit Polyclonal Antibody
SKU:
CAB20019
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 600-722 of human BRD4 (NP_055114.1).
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
23476
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and BRD4 knockout (KO) HeLa cells, using [KO Validated] BRD4 Rabbit pAb (CAB20019) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
