[KO Validated] MEK2 Rabbit Monoclonal Antibody (CAB19078)
- SKU:
- CAB19078
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | [KO Validated] MEK2 Rabbit Monoclonal Antibody |
SKU: | CAB19078 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MEK2 (P36507). |
Sequence: | MLAR RKPV LPAL TINP TIAE GPSP TSEG ASEA NLVD LQKK LEEL ELDE QQKK RLEA FLTQ KAKV GELK DDDF ERIS ELGA GNGG VVTK VQHR PSGL IMAR |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CFC4; MEK2; MKK2; MAPKK2; PRKMK2; [KO/KD Validated] MEK2 |
Positive Sample: | Jurkat,Mouse kidney,Mouse lung,HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Membrane, Peripheral membrane protein. |
Calculated MW: | 44kDa |
Observed MW: | 44kDa |
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5605 |
Clone Number: | ARC0361 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |