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APC Anti-Mouse CD272 Antibody [PK18.6] (AGEL0758)

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SKU AGEL0758
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone PK18.6
Conjugation APC
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Description

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APC Anti-Mouse CD272 Antibody [PK18.6]

The Mouse CD272 Monoclonal Antibody (APC conjugated) (PK18-6) is a powerful tool for researchers studying immune regulation and immune responses. This antibody, conjugated with APC for enhanced detection, targets CD272, a cell surface molecule with significant implications in immune modulation. CD272, also known as B- and T-lymphocyte attenuator (BTLA), is a key player in immune checkpoint regulation, influencing T cell activation and immune tolerance. By specifically binding to CD272, this monoclonal antibody allows for precise detection and analysis of CD272 expression in various cell types. Its primary application lies in immunology and cancer research, where understanding the role of CD272 can provide insights into immune evasion mechanisms in tumors and potential therapeutic targets for immunotherapy.

With its versatility and specificity, the Mouse CD272 Monoclonal Antibody (APC conjugated) (PK18-6) is a valuable asset for investigating immune checkpoints and their modulatory effects in both health and disease contexts. Its use can aid in unraveling the intricate interplay of immune regulatory pathways and pave the way for the development of novel treatment strategies in cancer and autoimmune disorders.

Product Title:APC Anti-Mouse CD272 Antibody [PK18.6]
SKU:AGEL0758
Size:25µg, 100µg
Clone No:PK18.6
Synonyms:B- and T-lymphocyte attenuator;Btla;B- and T-lymphocyte-associated protein;CD272;Btla;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG1, κ
Isotype Control:APC Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q7TSA3
Gene ID:208154
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and naïve T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.

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