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FITC Anti-Mouse CD272 Antibody [PK18.6] (AGEL3186)

SKU:
AGEL3186
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG1, k
Clone:
PK18.6
Conjugation:
FITC
€159 - €409
Frequently bought together:

Description

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FITC Anti-Mouse CD272 Antibody [PK18.6]

The FITC Anti-Mouse CD272 Antibody (PK18-6) is an essential tool for researchers studying immune responses and cell signaling pathways in mice. This monoclonal antibody, produced by Assay Genie, is highly specific to the CD272 protein, also known as BTLA (B and T lymphocyte attenuator). The antibody is conjugated with FITC (fluorescein isothiocyanate), allowing for easy detection and visualization of CD272 expression in various mouse tissues and cell types. It is suitable for use in flow cytometry, immunofluorescence, and immunohistochemistry applications, enabling precise localization and quantification of CD272 in experimental samples.CD272/BTLA is a critical immune checkpoint receptor that modulates T and B cell functions, serving as a key regulator of immune responses.

Research on CD272 has revealed its role in immune tolerance, autoimmunity, and anti-tumor immunity, making it a promising target for therapeutic interventions in conditions like cancer and autoimmune diseases.By utilizing the FITC Anti-Mouse CD272 Antibody (PK18-6) from Assay Genie, researchers can further explore the intricate mechanisms of immune regulation mediated by CD272, advancing our understanding of immune modulation and paving the way for novel therapeutic strategies in immunology and oncology.

Product Title:FITC Anti-Mouse CD272 Antibody [PK18.6]
SKU:AGEL3186
Size:25µg, 100µg
Clone No:PK18.6
Synonyms:B- and T-lymphocyte attenuator;Btla;B- and T-lymphocyte-associated protein;CD272;Btla;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG1, κ
Isotype Control:FITC Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q7TSA3
Gene ID:208154
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and naïve T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.

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