The NFX1 Polyclonal Antibody (PACO10839) is a valuable tool for researchers studying NFX1, a transcription factor involved in DNA repair and gene expression regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting NFX1 in human samples, making it ideal for use in Western blot applications. By targeting the NFX1 protein, this antibody enables precise detection and analysis in a variety of cell types, facilitating research in fields such as DNA repair mechanisms, gene regulation, and cancer biology.NFX1 plays a crucial role in maintaining genome stability and controlling gene expression, making it a key player in cellular homeostasis and response to various stressors.
Its involvement in DNA repair pathways and transcription regulation links NFX1 to a range of diseases, including cancer and genetic disorders. Understanding the functions of NFX1 is essential for advancing research in these areas and potentially identifying new therapeutic targets for intervention.Overall, the NFX1 Polyclonal Antibody (PACO10839) is a reliable tool for researchers interested in unraveling the intricate mechanisms of DNA repair, gene expression regulation, and disease pathways associated with NFX1. Its high specificity and validated performance make it a valuable asset for immunology, oncology, and molecular biology studies.
Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.
UniProt Protein Details:
NCBI Summary:
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008]
