The NME1/NM23A Monoclonal Antibody (CAB8802) is a high-quality antibody developed for reliable detection and analysis of target proteins. This highly specific antibody, produced in rabbits, has been rigorously validated for use in Western blot applications with human samples. It binds specifically to NM23A, allowing for precise detection and analysis in a variety of cell types.NM23A, also known as nucleoside diphosphate kinase A, is a multifunctional protein that plays a key role in various cellular processes, including DNA repair and signal transduction. Its dysregulation has been linked to cancer progression and metastasis, making NM23A a promising target for cancer research.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
NME1/NM23A Monoclonal Antibody
SKU:
CAB8802
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC1309
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
Purification Method
Affinity purification
Gene ID
4830
RRID
AB_2863611
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using NME1/NME1/NM23A Rabbit mAb (CAB8802) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
