The PARP14 Antibody (PAC054510) is a powerful tool for researchers studying the PARP14 protein, a member of the poly (ADP-ribose) polymerase (PARP) family that plays a crucial role in cellular processes such as DNA repair and gene regulation. This polyclonal antibody, produced in rabbits, is highly specific to human samples and has been extensively validated for use in Western blot applications.PARP14 is known to be involved in a variety of biological pathways, including inflammation, immune response, and cancer development. By targeting the PARP14 protein, researchers can gain insights into its function and potential therapeutic applications in diseases such as cancer and autoimmune disorders.
This antibody provides a reliable tool for detecting and analyzing PARP14 expression in different cell types, making it an essential component for studies in molecular biology and drug discovery. Overall, the PARP14 Antibody (PAC054510) is a valuable resource for researchers looking to deepen their understanding of the role of PARP14 in health and disease, paving the way for innovative research and therapeutic developments.
Antibody Name:
PARP14 Antibody (PACO54510)
Antibody SKU:
PACO54510
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Poly [ADP-ribose] polymerase 14 protein (1600-1712AA)
PARP14: Enhances STAT6-dependent transcription. Has ADP-ribosyltransferase activity. 5 isoforms of the human protein are produced by alternative splicing.Protein type: EC 2.4.2.30; Transcription, coactivator/corepressor; TransferaseChromosomal Location of Human Ortholog: 3q21.1Cellular Component: cytoplasm; cytosol; membrane; nucleusMolecular Function: enzyme binding; NAD+ ADP-ribosyltransferase activity; protein binding; RNA bindingBiological Process: innate immune response; negative regulation of gene expression; negative regulation of tyrosine phosphorylation of STAT protein; positive regulation of interleukin-4-mediated signaling pathway; positive regulation of tyrosine phosphorylation of STAT protein; protein ADP-ribosylation; regulation of transcription, DNA-templated; transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]
