Phospho-ACACA-S79 pAb (CABP0873)

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SKU:
CABP0873
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Description

Technical Manual

Phospho-ACC1-S79 Rabbit Polyclonal Antibody

Product Name:Phospho-ACC1-S79 Rabbit Polyclonal Antibody
Product SKU:CABP0873
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.

Immunogen:A phospho specific peptide corresponding to residues surrounding S79 of human ACC1
Sequence:

Email for sequence

Gene ID:31
Swiss Prot:Q13085
Synonyms:ACACA; ACAC; ACACAD; ACC; ACC1; ACCA
Calculated MW:257kDa/259kDa/265kDa/269kDa
Observed MW:Refer to figures
Reactivity:Human
Application:IHC
Recommended Dilution:IHC 1:500 - 1:2000
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application Key:Immunohistochemistry 
Positive Samples:
Cellular Location:Cytoplasm

Uniprot Information

UniProt Protein Function:ACC1: a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland. ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity.
UniProt Protein Details:

Protein type:Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; Ligase; EC 6.4.1.2; EC 6.3.4.14; Lipid Metabolism - fatty acid biosynthesis

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: actin cytoskeleton; cytoplasm; cytosol; mitochondrion; nucleolus

Molecular Function:acetyl-CoA carboxylase activity; ATP binding; biotin carboxylase activity; metal ion binding; protein binding

Biological Process: acetyl-CoA metabolic process; biotin metabolic process; carnitine shuttle; cellular lipid metabolic process; energy reserve metabolic process; fatty acid biosynthetic process; lipid homeostasis; multicellular organismal protein metabolic process; positive regulation of cellular metabolic process; protein homotetramerization; tissue homeostasis; triacylglycerol biosynthetic process; vitamin metabolic process; water-soluble vitamin metabolic process

Disease: Acetyl-coa Carboxylase Deficiency

NCBI Summary:Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q13085
NCBI GenInfo Identifier:118601083
NCBI Gene ID:31
NCBI Accession:Q13085.2
UniProt Secondary Accession:Q13085,Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564 Q86WB2, Q86WB3, B2RP68,
UniProt Related Accession:Q13085
Molecular Weight:269,999 Da
NCBI Full Name:Acetyl-CoA carboxylase 1
NCBI Synonym Full Names:acetyl-CoA carboxylase alpha
NCBI Official Symbol:ACACA 
NCBI Official Synonym Symbols:ACC; ACAC; ACC1; ACCA; ACACAD 
NCBI Protein Information:acetyl-CoA carboxylase 1
UniProt Protein Name:Acetyl-CoA carboxylase 1
UniProt Synonym Protein Names:ACC-alphaIncluding the following 1 domains:Biotin carboxylase (EC:6.3.4.14
UniProt Gene Name:ACACA 
UniProt Entry Name:ACACA_HUMAN
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Additional Information

Product type:
Antibody
Application:
IHC
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
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