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Human 2B4/CD244 Recombinant Protein (RPES2743)

SKU:
RPES2743
Product Type:
Recombinant Protein
Species:
Human
$787
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Description

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Human 2B4/CD244 Recombinant Protein

The CD244 antigen; also known as 2B4; is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of the signaling lymphocyte activation molecule (SLAM)-related receptor family and is important for stimulating NK cell cytotoxicity and cytokine production; which is expressed on all NK cells; a subpopulation of T cells; monocytes and basophils. The 2B4 antigen identified on NK cells and T cells is capable of transmitting stimulatory signals and non-MHC-restricted killing. Reported as an activating receptor; human 2B4 can effectively activate and enhance NK cell–mediated cytotoxicity; induce secretion of IFN-γ and matrix metalloproteinases (MMPs); as well as NK cell invasiveness. As a cell surface glycoprotein of the Ig-superfamily structurally related to CD2-like molecules such as CD2; CD48; CD58; CD84; Ly-9; and SLAM; 2B4 (CD244) is expressed on all human NK cells; a subpopulation of T cells; basophils and monocytes. 2B4 activates NK cell mediated cytotoxicity; induces secretion of IFN-gamma and matrix metalloproteinases; and NK cell invasiveness.Immune CheckpointImmune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: FCM AntibodiesImmune Checkpoint ProteinsImmune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets Immunotherapy   Cancer Immunotherapy   Targeted Therapy