Recombinant Human Arginase-1 Protein (His Tag) (RPES8604)
Arginase 1, also known as liver arginase, is a binuclear manganese metalloenzyme. It is a key enzyme of the urea cycle that catalyses the conversion of L-arginine into L-ornithine and urea, the final cytosolic reaction of urea formation in the mammalian liver. Arginase 1 is abundantly expressed in liver, but it is also expressed in cells and tissues that lack a complete urea cycle, including lung. Arginase is a critical regulator of nitric oxide synthesis and vascular function. It is implicated in a variety of human diseases including vascular disease, pulmonary disease, infectious disease, immune cell function and cancer. In humans, hereditary defects in arginase result in an accumulation of arginine in the blood known as hyperarginemia. Arginase deficiency can also result in the accumulation of nitrogen in the form of ammonia, which results in hyperammonemia.
Product Name:
Recombinant Human Arginase-1 Protein (His Tag)
SKU:
RPES8604
Size:
20μg, 100μg, 500μg, 1mg
Species:
Human
Synonyms:
ARG1, Al, Arginase 1, Arginase liver
Tag:
N-His
Sequence:
Met1-Lys322
Expression Host:
E.coli
Accession:
P05089
Purity:
> 90% as determined by reducing SDS-PAGE.
Endotoxin:
< 10 EU/mg of the protein as determined by the LAL method
Bio-Activity:
Not validated for activity
Form:
Lyophilized powder
Formulation:
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Storage:
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping:
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
