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Human CCL8/MCP-2 Recombinant Protein (RPES4944)

SKU:
RPES4944
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Chemokines
$265
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Description

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Human CCL8/MCP-2 Recombinant Protein

Human Chemokine (C-C Motif) Ligand 8 (CCL8) is produced by human MG63 osteosarcoma cells. CCL8 shares 62% and 58% amino acid sequence identity with MCP-1 and MCP-3; respectively. All three MCP proteins are monocyte chemoattractants. CCL8 is chemotactic for and activates many different immune cells; including mast cells; eosinophils and basophils; which are implicated in allergic response; and monocytes; T cells; and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors including CCR1; CCR2B and CCR5.