Human CEACAM1/CD66a Recombinant Protein (RPES3964)

SKU:
RPES3964
Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
$130

Description

ELISA Kit Technical Manual

Recombinant Human CEACAM1/CD66a Protein (His Tag)

Background:Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) is a member of the Carcinoembryonic Antigen (CEA) family, which belongs to the immunoglobulin superfamily. CEACAM1 is originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it is found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. CEACAM1 mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. In addition, CEACAM1 plays a important role in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses.
Name:Recombinant Human CEACAM1/CD66a Protein (His Tag)
Size:10µg
Assay Genie SKU:RPES3964
Synonyms:Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1; Biliary Glycoprotein 1; BGP; CD66a; CEACAM1; BGP; BGP1
Species:Human
Expression host:Human Cells
Sequence:Gln35-Gly428
Accession:P13688
Mol Mass:44.33 kDa
AP Mol Mass:90 kDa
Tag:C-His
Purity:> 90% as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per ?g as determined by the LAL method.
Storage:Lyophilized protein should be stored at < -20'C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7? for 2-7 days.Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:CEACAM1: carcinoembryonic antigen-related cell adhesion molecule 1. A cell-cell adhesion molecule that directly associates with annexin II. Has tumor suppressor activity in prostate carcinoma. Belongs to the immunoglobulin superfamily and the CEA family. Abundantly expressed in epithelia, vessel endothelia, trophoblasts, platelets and neutrophilic granulocytes. Also present in many cell types of the immune system such as B cells, T cells, NK cells, macrophages and dendritic cells. Five alternatively spliced isoforms have been described. Two isoforms are type I membrane proteins, while three are secreted.
UniProt Protein Details:

Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Immunoglobulin superfamily; Cell adhesion

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: membrane; integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function:protein binding; protein homodimerization activity

Biological Process: integrin-mediated signaling pathway; cell migration; angiogenesis; homophilic cell adhesion; blood coagulation; leukocyte migration

NCBI Summary:This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]
UniProt Code:P13688
NCBI GenInfo Identifier:399116
NCBI Gene ID:634
NCBI Accession:P13688.2
UniProt Related Accession:P13688
Molecular Weight:
NCBI Full Name:Carcinoembryonic antigen-related cell adhesion molecule 1
NCBI Synonym Full Names:CEA cell adhesion molecule 1
NCBI Official Symbol:CEACAM1  
NCBI Official Synonym Symbols:BGP; BGP1; BGPI  
NCBI Protein Information:carcinoembryonic antigen-related cell adhesion molecule 1
UniProt Protein Name:Carcinoembryonic antigen-related cell adhesion molecule 1
UniProt Synonym Protein Names:Biliary glycoprotein 1; BGP; CD_antigen: CD66a
Protein Family:CEACAM1-like protein
UniProt Gene Name:CEACAM1  
UniProt Entry Name:CEAM1_HUMAN
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