Recombinant Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein
The Recombinant Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein is a biologically active recombinant protein that plays a significant role in various cellular processes and signaling pathways in human biology. This protein is widely employed in immunological research, cell biology studies, protein-protein interaction analyses, and therapeutic development, providing researchers with a reliable tool for investigating Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer function and its implications in health and disease.
This product (SKU: RPCB1643) is produced using HEK293 cells and features a C-His&Avi tag for convenient detection and purification. The protein exhibits a calculated molecular weight of 114 kDa (ITGAV)&79.1 kDa (ITGB6) with an observed molecular weight of 90-150 kDa under denaturing conditions, achieving ≥ 95 % as determined by Tris-Bis PAGE;≥ 95 % as determined by HPLC., ensuring exceptional quality and consistency for research applications.
Key Features
High Purity by Affinity Chromatography
Mammalian & Bacterial Expression Systems
High lot-to-lot consistency via strict QC
Product Name:
Recombinant Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein
High quality, high purity and low endotoxin recombinant Recombinant Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein (RPCB1643), tested reactivity in HEK293 cells and has been validated in SDS-PAGE.100% guaranteed.
Endotoxin:
< 1 EU/μg of the protein by LAL method.
Purity:
≥ 95 % as determined by Tris-Bis PAGE;≥ 95 % as determined by HPLC.
Reconstitution:
Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
Storage:
Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
Recombinant Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein was determined by Tris-Bis PAGE under reducing conditions.
The purity of Human ITGAV&ITGB6 is greater than 95% as determined by SEC-HPLC.
