Neuregulin-1 (heregulin-1/NRG1) is a neuregulin family protein. It's got four genes that encode a number of secreted or membrane-bound variants. The EGF-like domain of all family members interacts with the ErbB family of tyrosine kinase receptors. There are three types of NRG1 proteins, or isoforms: type I, II, and III. NRG1 directs ligand for ERBB3 and ERBB4 tyrosine kinase receptors; concomitantly recruits ERBB1 and ERBB2 coreceptors; resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG proteins show distinct spatial and temporal expression patterns and play important roles during development of both the nervous system and the heart. Pro-Neuregulin/NRG1-beta 1 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Pro-Neuregulin/NRG1-beta 1 Recombinant Protein (RPES2828)
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Neuregulin-1 beta is produced by our E.coli expression system and the target gene encoding Thr176-Lys246 is expressed.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
8.2 kDa
AP Mol Mass:
7 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM PB;150mM NaCl;pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
