SHISA3 encodes a single-transmembrane protein which is one of nine members of a family of transmembrane adaptors that modulate both WNT and FGF signaling by blocking the maturation and transport of their receptors to the cell surface. Members of this family contain an N-terminal cysteine-rich domain with a distinct cysteine pattern, a single transmembrane domain, and a C-terminal proline-rich, low complexity region. The encoded protein acts as a tumor suppressor by accelerating beta-catenin degradation.
Product Name:
Human SHISA3 Recombinant Protein (RPES0403)
Product Code:
RPES0403
Size:
100 µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
hShisa3
Accession:
AAI27691.1
Sequence:
Met 1-Pro 98
Fusion tag:
C-Fc
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human SHISA3 (AAI27691.1) (Met1-Pro98) was expressed with the Fc region of mouse IgG1 at the C-terminus.
Purity:
>(13.6+78.2) % as determined by reducing SDS-PAGE..
Mol Mass:
34.9 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
