The Siglec11 Polyclonal Antibody (PAC020462) is a valuable tool for researchers studying Siglec11, a member of the Siglec family of proteins that play important roles in immune regulation. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for Western blot applications. By binding to the Siglec11 protein, this antibody enables the detection and analysis of Siglec11 in various cell types, providing valuable insights into its function in immunology and cancer research.
Siglec11 is known for its ability to modulate immune responses and is implicated in the regulation of inflammation and allergic reactions. Its role in immune homeostasis makes it a promising target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. By understanding the activity of Siglec11, researchers can uncover new therapeutic strategies that target immune function in these disease contexts.
Antibody Name:
SIGLEC11 Antibody (PACO20462)
Antibody SKU:
PACO20462
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human SIGLEC11
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO20462(SIGLEC11 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20462(SIGLEC11 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the sialic acid, binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid, recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms:
sialic acid, binding Ig-like lectin 11
UniProt Protein Function:
SIGLEC11: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8- linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 19q13.33
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
