UniProt Protein Function: | Probably plays an important role in neuronal membrane skeleton. |
UniProt Protein Details: | |
NCBI Summary: | Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009] |
UniProt Code: | O15020 |
NCBI GenInfo Identifier: | 5902122 |
NCBI Gene ID: | 6712 |
NCBI Accession: | NP_008877.1 |
UniProt Secondary Accession: | O15020 |
UniProt Related Accession: | O15020 |
Molecular Weight: | 246kDa |
NCBI Full Name: | spectrin beta chain, non-erythrocytic 2 |
NCBI Synonym Full Names: | spectrin beta, non-erythrocytic 2 |
NCBI Official Symbol: | SPTBN2Â Â |
NCBI Official Synonym Symbols: | SCA5; SCAR14; GTRAP41Â Â |
NCBI Protein Information: | spectrin beta chain, non-erythrocytic 2 |
UniProt Protein Name: | Spectrin beta chain, non-erythrocytic 2 |
UniProt Synonym Protein Names: | Beta-III spectrin; Spinocerebellar ataxia 5 protein |
Protein Family: | Spectrin |
UniProt Gene Name: | SPTBN2Â Â |
UniProt Entry Name: | |