The TMEM123 Polyclonal Antibody (PACO16883) is a crucial tool for researchers studying TMEM123, a transmembrane protein involved in various cellular processes. This antibody, produced in rabbits, demonstrates high specificity and sensitivity towards human samples, making it a reliable choice for Western blot applications. By targeting the TMEM123 protein, this antibody enables precise detection and analysis in different cell types, facilitating studies in areas such as cell biology and neurobiology.
TMEM123, also known as transmembrane protein 123, plays a vital role in cellular function by regulating processes such as cell signaling and membrane transport. Its involvement in these mechanisms underscores its importance in various physiological and pathological conditions, including neurological disorders and cancer. Investigating the functions of TMEM123 with this antibody is essential for unraveling its biological significance and potential therapeutic implications in related diseases.
Antibody Name:
TMEM123 Antibody (PACO16883)
Antibody SKU:
PACO16883
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:30-1:150
Species Reactivity:
Human
Immunogen:
Fusion protein of human TMEM123
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16883(TMEM123 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death.
Synonyms:
transmembrane protein 123
UniProt Protein Function:
Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.
UniProt Protein Details:
NCBI Summary:
This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]
