Anti-Transferrin Antibody (CAB19130)

SKU:
CAB19130
€129 - €349

Description

Technical Manual

Anti-Transferrin Antibody

Product Name:Anti-Transferrin Antibody
Product SKU:CAB19130
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

Immunogen:A synthesized peptide derived from human Transferrin
Sequence:

Email for sequence

Gene ID:7018
Swiss Prot:P02787
Synonyms:HEL-S-71p; PRO1557; PRO2086; TFQTL1; TF; Transferrin
Calculated MW:77kDa
Observed MW:77kDa
Reactivity:Human
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting Immunohistochemistry
Positive Samples:Human serum
Cellular Location:

Product Images

Anti-Transferrin Antibody (CAB19130)

Western blot - Transferrin Rabbit mAb (CAB19130)

Uniprot Information

UniProt Protein Function:TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: extracellular space; cell surface; early endosome; cytoplasmic membrane-bound vesicle; extracellular region; coated pit; recycling endosome; perinuclear region of cytoplasm; endocytic vesicle; apical plasma membrane; late endosome; basal plasma membrane; endosome membrane; vesicle

Molecular Function:protein binding; ferric iron binding; ubiquitin protein ligase binding

Biological Process: platelet activation; retinal homeostasis; platelet degranulation; cellular iron ion homeostasis; transferrin transport; blood coagulation; transmembrane transport

Disease: Atransferrinemia

NCBI Summary:This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]
UniProt Code:P02787
NCBI GenInfo Identifier:313104271
NCBI Gene ID:7018
NCBI Accession:P02787.3
UniProt Secondary Accession:P02787,O43890, Q1HBA5, Q9NQB8, Q9UHV0,
UniProt Related Accession:P02787
Molecular Weight:77,064 Da
NCBI Full Name:Serotransferrin
NCBI Synonym Full Names:transferrin
NCBI Official Symbol:TF
NCBI Official Synonym Symbols:TFQTL1; PRO1557; PRO2086
NCBI Protein Information:serotransferrin; siderophilin; beta-1 metal-binding globulin
UniProt Protein Name:Serotransferrin
UniProt Synonym Protein Names:Beta-1 metal-binding globulin; Siderophilin
Protein Family:Transferrin
UniProt Gene Name:TF
UniProt Entry Name:TRFE_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
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