Anti-Alpha-2C Adrenergic Receptor Antibody [N330A/80 (Formerly sold as S330A-80)]

Alpha-2C Adrenergic Receptor Antibody [N330A/80 (Formerly sold as S330A-80)]

Alpha-2C Adrenergic Receptor Antibody [N330A/80 (Formerly sold as S330A-80)] is a mouse monoclonal antibody directed against Alpha-2C Adrenergic Receptor, offered by Assay Genie for research applications. Reported applications include WB and ICC/IF. Reported reactivity: Human and Mouse. Supplied as IgG1, purified by Protein G.

The Alpha-2C Adrenergic Receptor (ADRA2C) is a G protein-coupled receptor that plays a critical role in modulating neurotransmitter release from central adrenergic neurons and sympathetic nerves, particularly in the brain and heart. Widely expressed in the central nervous system, ADRA2C is involved in regulating synaptic transmission, stress responses, and higher-order cognitive and behavioral functions. Two isoforms of ADRA2C are produced via alternative splicing, with predominant expression in brain regions implicated in memory, emotion, and executive function. Beyond the CNS, ADRA2C is also found in peripheral tissues including the heart, kidney, blood, and corpus cavernosum, suggesting a broader physiological role. In the context of neurodegenerative disease, dysregulation of ADRA2C signaling has been linked to impaired noradrenergic tone, altered synaptic plasticity, and neuroinflammation—key features observed in disorders such as Alzheimer’s disease, Parkinson’s disease, and schizophrenia. Its involvement in modulating cognitive resilience and behavioral regulation positions ADRA2C as a promising biomarker and therapeutic target in neuropsychiatric and neurodegenerative research. Ongoing studies are exploring ADRA2C agonists and antagonists for their potential to restore neurotransmitter balance, enhance cognitive function, and mitigate neurodegenerative progression This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.