Anti-FKBP51/FKBP5 Antibody (CAB9090)

Product Name:	FKBP51/FKBP5 Rabbit mAb
Product Code:	CAB9090
Size:	20uL, 50uL, 100uL
Synonyms:	AIG6, FKBP51, FKBP54, P54, PPIase, Ptg-10
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthesized peptide derived from human FKBP51/FKBP5

Applications:	WB, IHC
Recommended Dilutions:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	Mouse testis, Rat testis, HeLa, HT-1080, SH-SY5Y

Immunogen:	A synthesized peptide derived from human FKBP51/FKBP5
Purification Method:	Affinity purification
Storage:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	2289
Uniprot:	Q13451
Cellular Location:	Cytoplasm, Nucleus
Calculated MW:	51kDa
Observed MW:	51kDa

UniProt Protein Function:	FKBP5: Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP. Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from the complex when NR3C1 binds glucocorticoid. By androgen. Widely expressed, enriched in testis compared to other tissues. Inhibited by FK506 but not cyclosporin.
UniProt Protein Details:	Protein type:EC 5.2.1.8; Isomerase; Chaperone Chromosomal Location of Human Ortholog: 6p21.31 Cellular Component: nucleoplasm; endoplasmic reticulum membrane; membrane Molecular Function:protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; heat shock protein binding Biological Process: protein peptidyl-prolyl isomerization; protein folding Disease: Major Depressive Disorder
NCBI Summary:	The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
UniProt Code:	Q13451
NCBI GenInfo Identifier:	2851536
NCBI Gene ID:	2289
NCBI Accession:	Q13451.2
UniProt Related Accession:	Q13451
Molecular Weight:	51kDa
NCBI Full Name:	Peptidyl-prolyl cis-trans isomerase FKBP5
NCBI Synonym Full Names:	FKBP prolyl isomerase 5
NCBI Official Symbol:	FKBP5
NCBI Official Synonym Symbols:	P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10
NCBI Protein Information:	peptidyl-prolyl cis-trans isomerase FKBP5
UniProt Protein Name:	Peptidyl-prolyl cis-trans isomerase FKBP5
UniProt Synonym Protein Names:	51 kDa FK506-binding protein; 51 kDa FKBP; FKBP-51; 54 kDa progesterone receptor-associated immunophilin; Androgen-regulated protein 6; FF1 antigen; FK506-binding protein 5; FKBP-5; FKBP54; p54; HSP90-binding immunophilin; Rotamase
Protein Family:	FK506-binding protein
UniProt Gene Name:	FKBP5
UniProt Entry Name:	FKBP5_HUMAN