Anti-Mouse CTLA-4 [9H10] In Vivo Antibody

Product Name:	Anti-Mouse CTLA-4 [9H10] In Vivo Antibody - Ultra Low Endotoxin
Product Code:	IVMB0048
Size:	1mg, 5mg, 25mg, 50mg, 100mg
Clone:	9H10
Protein:	CLTA-4
Product Type:	Monoclonal Antibody
Synonyms:	CD152, Cytotoxic T Lymphocyte-Associated Antigen-4, Ly-56
Isotype:	Syrian Hamster IgG
Reactivity:	Mouse
Immunogen:	Mouse CTLA-4-human IgG1 fusion protein
Applications:	B, WB
Formulation:	This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Endotoxin Level:	<0.5 EU/mg as determined by the LAL method
Purity:	≥98% monomer by analytical SEC >95% by SDS Page
Preparation:	Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:	Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Product Code	Product Name	Endotoxin Level
IVMB0047	Anti-Mouse CTLA-4 [9H10] In Vivo Antibody - Low Endotoxin	Low
IVMB0048	Anti-Mouse CTLA-4 [9H10] In Vivo Antibody - Ultra Low Endotoxin	Ultra Low

Applications:	B, WB
Reactivity:	Mouse

Host Species:	Syrian Hamster
Specificity:	Anti-Mouse CLTA-4 (Clone 9H10) recognizes an epitope on Mouse CD152. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. This antibody was also pathogen tested and third-party certified by IDEXX BioReseach to meet the lowest mycoplasma specification and free of any viral pathogens of concern.
Antigen Distribution:	Activated T cells
Immunogen:	Mouse CTLA-4-human IgG1 fusion protein
Concentration:	≥ 5.0 mg/ml
Endotoxin Level:	<0.5 EU/mg as determined by the LAL method
Purity:	≥98% monomer by analytical SEC >95% by SDS Page
Formulation:	This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Preparation:	Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:	Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) also known as CD152, is a protein which is expressed on the surface of Helper T cells and plays an important regulatory role in the immune system.1 CTLA4 is a member of the immunoglobulin superfamily, expressed on the surface of Helper T cells. CTLA4 transmits an inhibitory signal to T cells.2,3 CTLA4 is potentially therapeutic in autoimmune diseases4, such as rheumatoid arthritis, HIV, autoimmune thyroid disease, multiple sclerosis and may also be useful during organ transplantation and cancer treatment. The 9H10 antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding.

Technical Datasheet:	View
Protein:	CLTA-4
Function:	Negative regulator of T cell activation
Ligand/Receptor:	CD80 (B7.1), CD86 (B7.2)
Research Area:	Immunology

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