The SERPING1 Monoclonal Antibody (CAB19259) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, has been validated for use in various applications, including Western blot analysis, making it ideal for investigating the role of Serping1 in immune responses and inflammatory pathways.Serping1, also known as C1 inhibitor, is a crucial regulator of the complement system, which plays a critical role in innate immunity and inflammation. Dysregulation of Serping1 has been implicated in various diseases, including hereditary angioedema and other inflammatory disorders.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
SERPING1 Monoclonal Antibody
SKU:
CAB19259
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC2427
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:
SLKL YHAF SAMK KVET NMAF SPFS IASL LTQV LLGA GENT KTNL ESIL SYPK DFTC VHQA LKGF TTKG VTSV SQIF HSPD LAIR DTFV NASR TLYS SSPR V
Tested Applications:
WBELISA
Recommended Dilution:
WB
1:500 - 1:1000
ELISA
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
C1IN, C1NH, HAE1, HAE2, C1INH, SERPING1
Positive Sample:
Human plasma, Mouse plasma, Rat plasma
Cellular Localization:
Secreted.
Calculated MW:
55kDa
Observed MW:
100kDa
This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its encoded protein, C1 inhibitor, inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. It is synthesized in the liver, and its deficiency is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform.
Purification Method
Affinity purification
Gene ID
710
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using SERPING1 Rabbit mAb (CAB19259) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
