Cell Death

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system_update_altDatasheetHuman TNFRSF19/TROY Recombinant Protein Tumor necrosis factor receptor superfamily; member 19 (TNFRSF19); also known as TAJ-alpha or TROY; is a member of the TNF-receptor superfamily. TNFRSF19/TROY expression is detected in the...

system_update_altDatasheetHuman TNFRSF19/TROY Recombinant Protein Tumor necrosis factor receptor superfamily; member 19 (TNFRSF19); also known as TAJ-alpha or TROY; is a member of the TNF-receptor superfamily. TNFRSF19/TROY expression is detected in the...

system_update_altDatasheetHuman CD27/TNFRSF7 Recombinant Protein CD27 antigen is also known as CD27L receptor; T-cell activation antigen CD27; Tumor necrosis factor receptor superfamily member 7; T14 and TNFRSF7. In humans; it is encoded by the CD27 gene...

system_update_altDatasheetHJTB Recombinant Protein Jumping translocation breakpoint, also known as JTB, is a member of the JTB family. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomalsegments jumping to...

system_update_altDatasheetHuman RACK1/GNB2L1 Recombinant Protein Calmodulin-like protein 3 (CALML3) is similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinity, to cellular substrates...

system_update_altDatasheetHuman GITR/TNFRSF18 Recombinant Protein Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA?isformB and isformC is single-pass type I membrane protein and...

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system_update_altDatasheetHuman FIS1 Recombinant Protein Mitochondrial Fission 1 Protein (FIS1) is a member of the FIS1 family. FIS1 is a single-pass membrane protein and contains one TPR repeat. FIS1 is part of the mitochondrial complex that promotes...

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system_update_altDatasheetHuman APLP Recombinant Protein Amyloid-like protein 1 (APLP-1) is a member of the highly conserved amyloid precursor protein gene family. APLP1 is a membrane-associated glycoprotein that is cleaved by secretases in a manner...

system_update_altDatasheetHuman Galectin4/LGALS14 Recombinant Protein Galectin-14 is a member of the Galectin family of carbohydrate binding proteins. The members of Galectin family contain one or two carbohydrate recognition domains, which can bind...

system_update_altDatasheetHuman Caspase0/CASP10 Recombinant Protein Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most...

system_update_altDatasheetHuman GADD45 gamma/GADD45G Recombinant Protein Growth Arrest and DNA Damage-Inducible Protein GADD45 ? (GADD45G) is a nuclear protein which belongs to the GADD45 family. GADD45G is highly expressed in placenta. GADD45G interacts...

system_update_altDatasheetBMF/Bcl2 modifying factor Recombinant Protein BMF(Bcl2 modifying factor) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a...

system_update_altDatasheetHuman BCL2/Bcl-2 Recombinant Protein Bcl-2 is a member of a family of proteins that regulates outer mitochondrial membrane permeability. Bcl-2 is an antiapoptotic member that prevents release of cytochrome c from the...

system_update_altDatasheetHuman BCL2L1/Bcl-XL Recombinant Protein Bcl-2-Like Protein 1 (BCL2L1) is a member of the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a...

system_update_altDatasheetHuman APLP Recombinant Protein APLP1, also known as amyloid-like protein 1, is a member of the highly conserved amyloid precursor protein gene family. APLP1 is a membrane-associated glycoprotein that is cleaved by secretases in...

system_update_altDatasheetHuman TNFRSF1B/CD120b Recombinant Protein Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor...

system_update_altDatasheetHuman BIM/BCL2L11 Recombinant Protein BIML is one of several splice variants of BIM, a proapoptotic protein belonging to the BH-3 domain-only subgroup of Bcl-2 family members. BCL-2 family members form hetero- or homodimers and...

system_update_altDatasheetHuman TNFRSF1B/CD120b Recombinant Protein Tumor necrosis factor receptor superfamily member 1B is a 461 amino acids protein that belongs to the TNFR (tumor necrosis factor receptor) superfamily characterized by cysteine-rich...

system_update_altDatasheetHuman TRAIL R4/TNFRSF10D Recombinant Protein Human TRAIL R4 is a type 1, TNF R family membrane protein, which is a receptor for TRAIL (APO2 ligand). TRAIL R4 contains an extracellular TRAIL-binding domain, a transmembrane...

system_update_altDatasheetHuman TGFBR2 Recombinant Protein TGFBR2 is a single-pass type I membrane protein and contains one protein kinase domain. TGFBR2 exsits as a heterodimeric complex with another receptor protein and binds TGF-beta. Signals...

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system_update_altDatasheetHuman S100A8 Recombinant Protein Protein S100-A8 (also MRP8 and calgranulin A) is a calcium- and zinc-binding protein.It plays a prominent role in the regulation of inflammatory processes and immune response. S100A8 can induce...

system_update_altDatasheetHuman TNFRSF1B/CD120b Recombinant Protein Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) is a member of the tumor necrosis factor receptor superfamily. Human TNF RII contains four cysteinerich repeats in its...

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system_update_altDatasheetHuman LTBR/TNFRSF3 Recombinant Protein Tumor necrosis factor receptor superfamily member 3; also known as Lymphotoxin-beta receptor;Tumor necrosis factor C receptor;Tumor necrosis factor receptor 2-related protein;Tumor necrosis...

system_update_altDatasheetHuman LTBR/TNFRSF3 Recombinant Protein Tumor necrosis factor receptor superfamily member 3; also known as Lymphotoxin-beta receptor;Tumor necrosis factor C receptor;Tumor necrosis factor receptor 2-related protein;Tumor necrosis...

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system_update_altDatasheetHuman PTH2/PTRH2 Recombinant Protein PTH2, also known as PTRH2, is a mitochondrial protein which belongs to the PTH2 family. PTH 2 is released during apoptosis from the mitochondria to the cytoplasm. The natural substrate for...

system_update_altDatasheetHuman RELT/TNFRSF19L Recombinant Protein Tumor necrosis factor receptor superfamily member 19L (TNFRSF19L), also known as Receptor expressed in lymphoid tissues and RELT, is a member of the TNF-receptor superfamily. TNFRSF19L is...

system_update_altDatasheetHuman HtrA2/Omi Recombinant Protein High temperature requirement protein A2(HTRA2) is a single-pass membrane protein .It contains 1 PDZ (DHR) domain and belongs to the peptidase S1C family. HtrA2 can be released from the...

system_update_altDatasheetHuman HtrA2/Omi Recombinant Protein Serine protease HTRA2, also known as high temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI and HTRA2, is a single-pass...

system_update_altDatasheetHuman BNIP3/NIP3 Recombinant Protein BCL2/Adenovirus E1B 19 kDa Protein-Iinteracting Protein 3 (BNIP3) is a single-pass membrane protein. BNIP3 is a member of the NIP3 family. BNIP3 contains a single Bcl-2 homology 3 domain and...

system_update_altDatasheetHuman CHI3L1/YKL40 Recombinant Protein Chitinase-3-Like Protein 1 (CHI3L1) belongs to the glycosyl hydrolase 18 family. CHI3L1 is expressed in activated macrophages, articular chondrocytes, synovial cells as well as in liver. It...

system_update_altDatasheetHuman BCL-W/BCL2L2 Recombinant Protein Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral...

system_update_altDatasheetHuman BAX/BCL2L4 Recombinant Protein Apoptosis Regulator BAX (BAX) belongs to the Bcl-2 family. BAX exists as a homodimer and is expressed in a wide variety of tissues. The Bax gene encodes different isoforms including Bax alpha...

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system_update_altDatasheetBeta-amyloid 39/Beta-APP39 Recombinant Protein Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons; and is suggested as a regulator of synapse...

system_update_altDatasheetHuman ERO1A/ERO1L Recombinant Protein ERO1-Like Protein ? (ERO1L) is an enzyme that belongs to the EROs family. ERO1L is expressed at high level in esophagus and upper digestive tract. ERO1L is an essential oxidoreductase that...

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system_update_altDatasheetHuman AIFM1 Recombinant Protein Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells...

system_update_altDatasheetHuman EphA7/EHK3 Recombinant Protein Ephrin Type-A Receptor 7 (EPHA7) is a single-pass type I membrane protein which belongs to the Eph family of transmembrane receptor tyrosine kinases. It contains two fibronectin type-III...

system_update_altDatasheetHuman PCSK9 Recombinant Protein Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9/PCSK9 (D374Y) is a gain of function mutant of human PCSK9 protein. Human PCSK9 is a secretory subtilase belonging to the proteinase...

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system_update_altDatasheetHuman PCSK9 Recombinant Protein Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic...

system_update_altDatasheetHuman PCSK9 Recombinant Protein Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic...

system_update_altDatasheetHuman PCSK9 Recombinant Protein Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic...

system_update_altDatasheetHuman C1D Recombinant Protein C1D nuclear receptor corepressor belongs to the C1D family. It is a DNA binding and apoptosis-inducing protein.C1D nuclear receptor corepressorinteracts with TSNAX and DNA-PKcs. It acts as a...

system_update_altDatasheetHuman CASP7/caspase 7 Recombinant Protein Caspase 7, also known as caspase-7 and MCH3, belongs to the cysteine-aspartic acid protease (caspase) family. Caspases play a role in the signal transduction pathways of apoptosis,...

system_update_altDatasheetHuman GITR/TNFRSF18 Recombinant Protein Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA?isformB and isformC is single-pass type I membrane protein and...

system_update_altDatasheetHuman DFFA Recombinant Protein DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the...

system_update_altDatasheetHuman UBE2Z Recombinant Protein Ubiquitin-Conjugating Enzyme E2 Z (ZUBE2Z) is a member of the E2 ubiquitin-conjugating enzyme family. ZUBE2Z is widely expressed in many tissues, with high expression found in the placenta,...

system_update_altDatasheetHuman GAPDH Recombinant Protein Glyceraldehyde 3-phosphate dehydrogenase (GAPDH or G3PDH) is an enzyme of about 37kDa that is consisdered as a cellular enzyme involved in glycolysis. It catelyzes the sixth step of glycolysis...

system_update_altDatasheetHuman PS6K/RPS6KB1 Recombinant Protein PS6K, also known as RPS6KB1, is a serine/threonine-protein kinase. It belongs to the RSK (ribosomal s6 kinase) family. Members of this family function in signal transduction. PS6K is an...

system_update_altDatasheetHuman TNFRSF25/DR3 Recombinant Protein Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) contains 1 death domain and 4 TNFR-Cys repeats. TNFRSF25 is a cell surface receptor of the tumor necrosis factor receptor...

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system_update_altDatasheetHuman DYNLL1 Recombinant Protein Human Dynein Cytoplasmic Light Chain 1 (DYNLL1) has been identified as a protein that interacts with NOS1, leading to NOS1 inhibition. NOS1 dimer is destabilized after binding DYNLL1 a...

system_update_altDatasheetHuman Cytochrome C/CYCS Recombinant Protein Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a...

system_update_altDatasheetHuman MKK6 Recombinant Protein Dual specificity mitogen-activated protein kinase kinase 6; also known as MAP kinase kinase 6; MAPKK 6; MAPK / ERK kinase 6; SAPKK3; MAP2K6 and MKK6; is a protein which belongs to the?protein...

system_update_altDatasheetHuman MKK6 Recombinant Protein Dual specificity mitogen-activated protein kinase kinase 6; also known as MAP kinase kinase 6; MAPKK 6; MAPK / ERK kinase 6; SAPKK3; MAP2K6 and MKK6; is a protein which belongs to the?protein...

system_update_altDatasheetHuman TGFBR1/ALK-5 Recombinant Protein Transforming growth factor, beta receptor I, also known as Transforming growth factor-beta receptor type I , Serine / threonine-protein kinase receptor R4, Activin receptor-like kinase 5,...

system_update_altDatasheetHuman CRADD/RAIDD Recombinant Protein Death domain-containing protein CRADD; also known as Caspase and RIP adapter with death domain; RIP-associated protein with a death domain; CRADD and RAIDD; is a protein which is...

system_update_altDatasheetHuman TNFRSF1B/CD120b Recombinant Protein Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) is a member of the tumor necrosis factor receptor superfamily. Human TNF RII contains four cysteinerich repeats in its...

system_update_altDatasheetHuman Cyclophilin D/PPID Recombinant Protein Peptidyl-Prolyl Cis-Trans Isomerase D (PPID) belongs to the cyclophilin-type PPIase family and PPIase D subfamily. PPID is widely expressed and it contains one PPIase cyclophilin-type...

system_update_altDatasheetHuman PDCD5/TFAR19 Recombinant Protein Programmed Cell Death Protein 5 (PDCD5) is a member of the PDCD5 family. PDCD5 is expressed in tumor cells during apoptosis, independent of apoptosis-inducing stimuli. This protein may...

system_update_altDatasheetHuman PDCD4/H731 Recombinant Protein Programmed Cell Death Protein 4 (PDCD4) is a member of the PDCD4 family. PDCD4 and EIF4A1 form a heterotrimer. One molecule of PDCD4 binds two molecules of EIF4A1. PDCD4 takes part in...

system_update_altDatasheetHuman STK4/MST1 Recombinant Protein MST1 protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease...

system_update_altDatasheetBeta-amyloid 40/Beta-APP40 Recombinant Protein Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons; and is suggested as a regulator of synapse...

system_update_altDatasheetBeta-amyloid 42/Beta-APP42 Recombinant Protein Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons; and is suggested as a regulator of synapse...

system_update_altDatasheetBeta-amyloid 38/Beta-APP38 Recombinant Protein Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons; and is suggested as a regulator of synapse...

system_update_altDatasheetHuman TRAIL R3/TNFRSF10C Recombinant Protein Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the...

system_update_altDatasheetHuman ERN1/IRE1 Recombinant Protein The encoded protein contains two functional catalytic domains; a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins...

system_update_altDatasheetHuman TRAIL R3/TNFRSF10C Recombinant Protein Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the...

system_update_altDatasheetHuman TRAIL R2/TNFRSF10B Recombinant Protein TNFRSF10B is a member of the TNF-receptor superfamily; and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing...

system_update_altDatasheetHuman DAPK1/DAP Kinase 1 Recombinant Protein Death-associated protein kinase 1, also known as DAP kinase 1, DAPK1 and DAPK, is a cytoplasm protein which belongs to the protein kinase superfamily, CAMK Ser / Thr protein...

system_update_altDatasheetOsteoprotegerin/TNFRSF11B Recombinant Protein TNFRSF11B is a secreted protein; containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL)...

system_update_altDatasheetHuman STK24/MST3 Recombinant Protein MST3 encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the...

system_update_altDatasheetHuman NOL3 Recombinant Protein Nucleolar Protein 3 is encoded by NOL3 gene; multiple transcript variants encoding different isoforms have been found for this gene. So far; Nucleolar protein 3 has show to have two Isoforms...

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system_update_altDatasheetHuman Clusterin/ApoJ Recombinant Protein Clusterin is a secreted protein which belongs to the Clusterin family. Clusterin is expressed in adult testis; heart; ovary; adrenal gland; brain and liver. Clusterin has been suggested...

system_update_altDatasheetHuman Clusterin/ApoJ Recombinant Protein Clusterin is a secreted protein which belongs to the Clusterin family. Clusterin is expressed in adult testis; heart; ovary; adrenal gland; brain and liver. Clusterin has been suggested...

system_update_altDatasheetOsteoprotegerin/TNFRSF11B Recombinant Protein TNFRSF11B is a secreted protein; containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL)...

system_update_altDatasheetHuman CD27/TNFRSF7 Recombinant Protein CD27; also known as TNFRSF7; is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage; and exists as both a dimeric glycoprotein on the cell surface and as a...

system_update_altDatasheetHuman CD27/TNFRSF7 Recombinant Protein CD27; also known as TNFRSF7; is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage; and exists as both a dimeric glycoprotein on the cell surface and as a...

system_update_altDatasheetHuman BCL2/Bcl-2 Recombinant Protein BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis...

system_update_altDatasheetHuman p63 Recombinant Protein Tumor protein p63 is a protein also known as transformation-related protein 63, TP63, and p63. Tumor protein p63 / p63 is a member of the p53 family of transcription factors whose members P53, p63,...

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system_update_altDatasheetHuman NGAL/Lipocalin-2 Recombinant Protein Neutrophil gelatinase-associated lipocalin(LCN2) is a secreted protein and belongs to the calycin superfamily. This protein is released from injured tubular cells after various damaging...

system_update_altDatasheetHuman Galectin-7/LGALS7 Recombinant Protein LGALS7; also known as Galectin-7; is a member of the galectins family. The galectins are a family of beta-galactoside-binding proteins. There are at least 14 identified members in this...

system_update_altDatasheetHuman NGAL/Lipocalin-2 Recombinant Protein LCN2 is iron-trafficking protein involved in multiple processes such as apoptosis; innate immunity and renal development. LCN2 binds iron through association with 2;5-dihydroxybenzoic...

system_update_altDatasheetHuman CEACAM5/CEA Recombinant Protein Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin related glycoproteins. They play critical roles in cell–cell recognition...

system_update_altDatasheetHuman CEACAM5/CEA Recombinant Protein Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin related glycoproteins. They play critical roles in cell–cell recognition...

system_update_altDatasheetHuman HER4/ErbB4 Recombinant Protein ErbB4 is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family...