Immune Checkpoint

Human CD32 Recombinant Protein (hFc Tag)Description:This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on...

Human NRG1 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety...

Human HGF Recombinant Protein (hFc Tag)Description:This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in...

Human CCR8 Recombinant Protein (hFc Tag)Description:This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are...

Human CD79B Recombinant Protein (hFc Tag)Description:The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins,...

Human IL21 Recombinant Protein (hFc Tag)Description:This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the...

Human CD43 Recombinant Protein (hFc Tag)Description:This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B...

Human IL20 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of...

Human IL18R1 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated...

Human GPC1 Recombinant Protein (hFc Tag)Description:Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral...

Human TM4SF1 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the...

Human IL18 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells...

Human IL1A Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis...

Human DKK2 Recombinant Protein (hFc Tag)Description:This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the...

Human VSIR Recombinant Protein (hFc Tag)Description:Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate...

Human CD6 Recombinant Protein (hFc Tag)Description:This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a...

Human TLR3 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved...

Human SIGLEC9 Recombinant Protein (hFc Tag)Description:Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by...

Human LGALS3 Recombinant Protein (hFc Tag)Description:This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an...

Human KRAS Recombinant Protein (hFc Tag)Description:This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an...

Human IFNAR1 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus...

Human HBL Recombinant Protein (hFc Tag)Description:The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that...

Human Gastrin Recombinant Protein (hFc Tag)Description:Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic...

Human FN1 Recombinant Protein (hFc Tag)Description:This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein...

Human CXCR2 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal...

Human CSF2RA Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of...

Human CCR2 Recombinant Protein (hFc Tag)Description:This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in...

Human CB2 Recombinant Protein (hFc Tag)Description:The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the...

Human ADAM9 Recombinant Protein (hFc Tag)Description:This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and...

Human IL1R1 Recombinant Protein (hFc Tag)Description:This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor...

Human NECTIN4 Recombinant Protein (hFc Tag)Description:This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through...

Human GDNF Recombinant Protein (hFc Tag)Description:This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and...

Human FOLR2 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid...

Human PROM1 Recombinant Protein (hFc Tag)Description:This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem...

Human VSIG4 Recombinant Protein (hFc Tag)Description:This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of...

Human NCR1 Recombinant Protein (hFc Tag)Description:Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.Product name:Human NCR1 Recombinant Protein (hFc...

Human KLRC1 Recombinant Protein (hFc Tag)Description:Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated...

Human CD9 Recombinant Protein (hFc Tag)Description:This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric...

Human CD99 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a...

Human IL-7RA Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by...

Human IL1B Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active...

Human LRRC32 Recombinant Protein (hFc Tag)Description:This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies.Product name:Human LRRC32 ...

Human CXC-R5 Recombinant Protein (hFc Tag)Description:This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to...

Human CXC-R4 Recombinant Protein (hFc Tag)Description:This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to...

Human CXC-R3 Recombinant Protein (hFc Tag)Description:This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and...

Human CLEC2D Recombinant Protein (hFc Tag)Description:This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well...

Human CEACAM-1 Recombinant Protein (hFc Tag)Description:This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and...

Human CD73 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant...

Human CCR9 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their...

Human CCR7 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of...

Human CCR4 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide,...

Human CEACAM6 Recombinant Protein (hFc Tag)Description:This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this...

Human IGF-1R Recombinant Protein (hFc Tag)Description:This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage...

Human CD21 Recombinant Protein (hFc Tag)Description:This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to...

Human ANPEP Recombinant Protein (hFc Tag)Description:Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of...

Human IL4RA Recombinant Protein (hFc Tag)Description:This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can...

Human GPA33 Recombinant Protein (hFc Tag)Description:The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a...

Human CDH3 Recombinant Protein (hFc Tag)Description:This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically...

Human CDH17 Recombinant Protein (hFc Tag)Description:This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region,...

Human AMHR2 Recombinant Protein (hFc Tag)Description:This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different...

Human IL15RA Recombinant Protein (hFc Tag)Description:This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis...

Human MUC1 Recombinant Protein (hFc Tag)Description:This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial...

Human PSMA Recombinant Protein (mFc Tag)Description:This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient...

Human PSMA Recombinant Protein (His Tag)Description:This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient...

Human YAP1 Recombinant Protein (His Tag)Description:This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and...

Human TMEM173 Recombinant Protein (hFc Tag)Description:This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition...

Human SLAMF3 Recombinant Protein (His Tag)Description:LY9 belongs to the SLAM family of immunomodulatory receptors (see SLAMF1, MIM 603492) and interacts with the adaptor molecule SAP (SH2D1A, MIM 300490) (Graham et al., 2006 [PubMed 16365421]).Product...

Human CD56 Recombinant Protein (hFc Tag)Description:This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during...

Human TM4SF1 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the...

Human IL5 Recombinant Protein (hFc Tag)Description:This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation,...

Human IL5RA Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta...

Human IL6R Recombinant Protein (hFc Tag)Description:This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the...

Human SFRP2 Recombinant Protein (His Tag)Description:This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling...

Human AXL Recombinant Protein (mFc Tag)Description:The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two...

Human AXL Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two...

Human SIRPα Recombinant Protein (mFc Tag)Description:Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein...

Human CD38 Recombinant Protein (hFc Tag)Description:CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta,...

Human BTLA Recombinant Protein (His Tag)Description:This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune...

Human BTLA Recombinant Protein (hFc Tag)Description:This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune...

Human MASP2 Recombinant Protein (hFc Tag)Description:This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature...

Human PSMA Recombinant Protein (hFc Tag)Description:This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient...

Human KLRG1 Recombinant Protein (hFc Tag)Description:Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated...

Human FOLR1 Recombinant Protein (His Tag)Description:The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells...

Human DKK1 Recombinant Protein (hFc Tag)Description:This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The...

Human CD56 Recombinant Protein (His Tag)Description:This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during...

Human PTK7 Recombinant Protein (hFc Tag)Description:This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic...

Human AFP Recombinant Protein (hFc Tag)Description:This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatocarcinoma and...

Human TGFB1 Recombinant Protein (hFc Tag)Description:This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and...

Human SLAMF3 Recombinant Protein (hFc Tag)Description:LY9 belongs to the SLAM family of immunomodulatory receptors (see SLAMF1, MIM 603492) and interacts with the adaptor molecule SAP (SH2D1A, MIM 300490) (Graham et al., 2006 [PubMed 16365421]).Product...

Human B7-H4 Recombinant Protein (hFc Tag)Description:This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors...

Human LIGHT Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor...

Human CD20 Recombinant Protein (hFc Tag)Description:This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and...

Human ANGPTL3 Recombinant Protein (His Tag)Description:This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal...

Human CD117 Recombinant Protein (His Tag)Description:This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical...

Human PDL2 Recombinant Protein (His Tag)Description:Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle...

Human CD160 Recombinant Protein (His Tag)Description:CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with...

Human IL13RA1 Recombinant Protein (His Tag)Description:The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit...

Human VEGFR2 Recombinant Protein (His Tag)Description:Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor,...

Human PVRIG Recombinant Protein (hFc Tag)Description:Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with...

Human CD160 Recombinant Protein (hFc Tag)Description:CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with...