Signal Transduction

system_update_altDatasheetHuman SUMO3/SMT3A Recombinant Protein SUMO3 belongs to the SUMO protein family and operates like ubiquitin. Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked...

system_update_altDatasheetHuman SUMO3/SMT3A Recombinant Protein Small ubiquitin-like modifier (SUMO); also known as SUMO homologue and SMT3; is a member of the superfamily of ubiquitin-like polypeptides that become covalently attached to various...

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system_update_altDatasheetHuman SUMO2 Recombinant Protein Small Ubiquitin-Related Modifier 2 (SUMO2) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be...

system_update_altDatasheetHuman Myeloperoxidase/MPO Recombinant Protein Myeloperoxidase (MPO) is a heme-containingenzyme belonging to the XPO subfamily of peroxidases. It is an abundant neutrophil and monocyte glycoprotein thatcatalyzes the hydrogen...

system_update_altDatasheetHuman SCN3B Recombinant Protein SCN3B (sodium channel; voltage-gated; type III; beta ;human IgG1-Fc chimera) belongs to the sodium channel auxiliary subunit SCN3B family. It contains 1 Ig-like C2-type (immunoglobulin-like)...

system_update_altDatasheetHuman SCN3B Recombinant Protein SCN3B (sodium channel; voltage-gated; type III; beta ;human IgG1-Fc chimera) belongs to the sodium channel auxiliary subunit SCN3B family. It contains 1 Ig-like C2-type (immunoglobulin-like)...

system_update_altDatasheetHuman USP5/ISOT Recombinant Protein Ubiquitin carboxyl-terminal hydrolase 5, also known as Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thiolesterase 5, Ubiquitin-specific-processing protease 5, ISOT and USP5, is a...

system_update_altDatasheetHuman MOB4/MOBKL3 Recombinant Protein MOB-Like Protein Phocein is a member of the MOB1/Phocein Family. MOB-Like Protein Phocein is associated with membranes and the Golgi stacks. It is present in the cytosol, where it behaves as...

system_update_altDatasheetHuman UBE2F Recombinant Protein UBE2F is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation,...

system_update_altDatasheetHuman DMP1 Recombinant Protein Dentin matrix acidic phosphoprotein (DMP1) is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for...

system_update_altDatasheetGastric intrinsic factor/GIF Recombinant Protein Gastric intrinsic factor, also known as GIF, belongs to the of the cobalamin transport protein family. It is a glycoprotein produced by the parietal cells of the stomach. Gastric...

system_update_altDatasheetHuman SENP8 Recombinant Protein Sentrin-Specific Protease 8 (SENP8) mediates the reversible covalent modification of proteins by NEDD8. SENP8 catalyzes the full-length NEDD8 to generate its mature form and deconjugation of NEDD8...

system_update_altDatasheetHuman SENP7 Recombinant Protein Sentrin-Specific Protease 7 (SENP7) acts as a SUMO-2/3-specific protease. SENP7 is likely to regulate the metabolism of poly-SUMO-2/3 rather than SUMO-1 conjugation in vivo. SENP7 has a restricted...

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system_update_altDatasheetHuman LYVE1/HAR Recombinant Protein Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 is a single-pass type I membrane protein. LYVE-1 is a CD44 homolog found primarily on lymphatic endothelial cells 1. LYVE-1 mainly...

system_update_altDatasheetHuman TROP2/TACSTD2 Recombinant Protein Tumor associated calcium signal transducer 2 (TACSTD2; TROP-2) is a type I cell surface glycoprotein that is highly expressed on human carcinomas. It was originally identified as an...

system_update_altDatasheetHuman TROP2/TACSTD2 Recombinant Protein Tumor associated calcium signal transducer 2 (TACSTD2; TROP-2) is a type I cell surface glycoprotein that is highly expressed on human carcinomas. It was originally identified as an...

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system_update_altDatasheetHuman RBP3 Recombinant Protein Retinol-binding proteins (RBP) are a family of proteins with diverse functions. They are carrier proteins that bind retinol. Retinol and retinoic acid play crucial roles in the modulation of gene...

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system_update_altDatasheetHuman Catalase/CAT Recombinant Protein Catalase is a ubiquitously expressed enzyme that catalyzes the decomposition of hydrogen peroxide to water and oxygen. It is a tetramer of four polypeptides chains containing four porphyrin...

system_update_altDatasheetHuman Fetuin-A/AHSG Recombinant Protein ?-2-HS Glycoprotein (AHSG) is a glycoprotein that is composed of two subunits, the A and B chains, belongs to the Cystatin family of proteases inhibitors. It is highly expressed in...

system_update_altDatasheetHuman Statherin/STATH Recombinant Protein Statherin, also known as STATH, belongs to the histatin/statherin family. Statherin may play an important role in the maintenance of oral health.It prevents calcium phospate...

system_update_altDatasheetHuman BLBP/FABP7 Recombinant Protein Fatty Acid-Binding Protein 7 (FABP7) is a cytoplasm protein that belongs to the Fatty-acid Binding Protein (FABP) family of calycin superfamily. Fatty acid binding proteins are a family of...

system_update_altDatasheetHuman L-FABP/FABP1 Recombinant Protein Human Fatty Acid-Binding Protein 1 (FABP1) is a cytoplasm protein, which belongs to the calycin superfamily and Fatty-acid binding protein (FABP) family. Fatty acid binding proteins are a...

system_update_altDatasheetHuman Transferrin Recombinant Protein Serotransferrin belongs to transferrin family, and contains 2 transferrin-like domains. The protein is a secreted protein, and expressed by the liver and secreted in plasma. Transferrins are...

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system_update_altDatasheetHuman RSPO3 Recombinant Protein R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling; plays a key role in these processes. The RSPO family of secreted Wnt...

system_update_altDatasheetHuman RSPO3 Recombinant Protein R-spondin-3 (RSPO3); also known as Protein with TSP type-1 repeat; Roof plate-specific spondin-3; Thrombospondin type-1 domain-containing protein 2; PWTSR; THSD2 and CRISTIN1; is a member of the...

system_update_altDatasheetHuman CLIC4 Recombinant Protein Chloride intracellular channel protein 4; also known as Intracellular chloride ion channel protein p64H1 and CLIC4; is a member of the chloride channel CLIC family. It contains one GST...

system_update_altDatasheetHuman Apolipoprotein D/ApoD Recombinant Protein Apolipoprotein-D (ApoD) is an atypical apolipoprotein and, based on its primary structure, it also a member of the lipocalin family. ApoD is mainly associated with high density...

system_update_altDatasheetHuman Kallikrein 4/KLK4 Recombinant Protein Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have...

system_update_altDatasheetHuman UBE2D1 Recombinant Protein Ubiquitin-conjugating enzyme E2 D1?UBE2D1?belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes; or E1s;...

system_update_altDatasheetHuman FABP2/I-FABP Recombinant Protein Fatty Acid-Binding Protein 2 (FABP2) is a cytoplasm protein that belongs to the Fatty-acid binding protein (FABP) family of calycin superfamily. Fatty acid binding proteins are a family of...

system_update_altDatasheetHuman FABP4/A-FABP Recombinant Protein Fatty Acid-Binding Protein 4 (FABP4) is a cytoplasm protein that belongs to the fatty-acid binding protein (FABP) family of calycin superfamily. Fatty acid binding proteins are a family of...

system_update_altDatasheetHuman FOLR2/FBP Recombinant Protein Folate receptor beta, also known as Folate receptor 2, FBP, and FOLR2, is a member of the folate receptor family. FOLR2 is expressed in placenta and hematopoietic cells. The expression of...

system_update_altDatasheetHuman EIF4EBP2 Recombinant Protein Eukaryotic Translation Initiation Factor 4E-Binding Protein 2 (EIF4EBP2) is a member of the Eukaryotic Translation Initiation Factor 4E Binding Protein Family. EIF4EBP2 regulates eIF4E activity...

system_update_altDatasheetHuman 4E-BP1/EIF4EBP1 Recombinant Protein Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 (4EBP1) is a number of the eIF4E-binding protein family. 4EBP1 regulates eIF4E activity by preventing its assembly into the...

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system_update_altDatasheetHuman Vitamin D-Binding Recombinant Protein Vitamin D-Binding Protein (DBP) is a member of the ALB/AFP/VDB family. DBP is a secreted protein and contains three albumin domains. The primary structure contains 28 cysteine residues...

system_update_altDatasheetHuman ASB13 Recombinant Protein Ankyrin repeat and SOCS box protein 13(ASB13) is a member of the ankyrin repeat and SOCS box-containing (ASB) family. ASB13 contain six ankyrin repeats sequence and a SOCS box domain. The SOCS box...

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system_update_altDatasheetAlkaline Phosphatase/ALPL Recombinant Protein Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL) is a cell membrane protein which belongs to the alkaline phosphatase family. There are at least four distinct but related...

system_update_altDatasheetHuman CD98 Recombinant Protein CD98 is a single-pass type I I membrane protein which belongs to the SLC3A transporter family. SLC3A2/MDU1 is expressed ubiquitously in all tissues tested with highest levels detected in kidney;...

system_update_altDatasheetHuman UBA5 Recombinant Protein UBA5 is a member of the ubiquitin-activating E1 family and UBA5 subfamily. Ubiquitin and ubiquitin-like proteins are recognized as covalently conjugated to various cellular substrates by a...

system_update_altDatasheetHuman DMP1 Recombinant Protein Dentin Matrix Acidic Phosphoprotein 1 (DMP-1) is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. DMP-1 is expressed in teeth...

system_update_altDatasheetHuman Ube2L6 Recombinant Protein UBCH8; also known as UBE2L6; belongs to the ubiquitin-conjugating enzyme family. The family of ubiquitin-conjugating (E2) enzymes is characterized by the presence of a highly conserved...

system_update_altDatasheetHuman UBE2V2/DDVIT1 Recombinant Protein Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2) is an enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2V2 can be detected in the placenta, colon, liver, and skin. It...

system_update_altDatasheetHuman CLIC4 Recombinant Protein Chloride Intracellular Channel Protein 4 (CLIC4) is a 253 amino acid single-pass membrane protein that localizes to both the nucleus and the cytoplasm and contains one GST C-terminal domain. CLIC4...

system_update_altDatasheetHuman UBE2V1 Recombinant Protein Ubiquitin-Conjugating Enzyme Variant 1a (UBE2V1) is a member of the Ubiquitin-conjugating (E2) enzyme family. The E2 catalytic core domain of UBE2V1 lacks an active site cysteine residue,...

system_update_altDatasheetHuman DCUN1D1 Recombinant Protein DCN1-Like Protein 1 is a protein containing 1 DCUN1 domain and 1 UBA-like domain. DCN1-Like Protein 1 contains part of an E3 Ubiquitin Ligase Complex for Neddylation. It is required for...

system_update_altDatasheetHuman UBE2R2/UBC3B Recombinant Protein Ubiquitin-Conjugating Enzyme E2 R2 (UBE2R2) is a modification enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2R2 is involved in cell growth and transformation. It...

system_update_altDatasheetHuman HIP2/UBE2K Recombinant Protein Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain; with highest levels found in cortex and striatum; and...

system_update_altDatasheetHuman HIP2/UBE2K Recombinant Protein Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain; with highest levels found in cortex and striatum; and...

system_update_altDatasheetHuman FABP3 Recombinant Protein Fatty Acid Binding Protein 3 (FABP3) is a small cytoplasmic protein (15 kDa) that is released from cardiac myocytes following an ischemic episode. Like the nine other distinct FABPs that have been...

system_update_altDatasheetHuman UBE2J2 Recombinant Protein Ubiquitin-Conjugating Enzyme E2 J2 (UBE2J2) belongs to the ubiquitin-conjugating enzyme family. UBE2J2 is involved in the ubiquitiantion. UBE2J2 located in the membrane of the endoplasmic...

system_update_altDatasheetHuman UBE2G2 Recombinant Protein Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation, which belong to the ubiquitin-conjugating enzyme...

system_update_altDatasheetHuman NCK1 Recombinant Protein Cytoplasmic Protein NCK1 (NCK1) is a cytoplasmic protein that contains one SH2 domain and three SH3 domains. NCK1 is a member of the adapter family, which associates with tyrosine-phosphorylated...

system_update_altDatasheetHuman Cytoglobin/CYGB Recombinant Protein Cytoglobin is a ubiquitously globin protein that belongs to the globin family. The highest expressed in heart, stomach, bladder and small intestine. CYGB acts a protector under...

system_update_altDatasheetHuman FABP5 Recombinant Protein Fatty acid-binding protein 5 (FABP5) is a cytoplasm protein that belongs to the fatty-acid binding protein (FABP) family of calycin superfamily. Fatty acid binding proteins are a family of small;...

system_update_altDatasheetHuman Ube2L6 Recombinant Protein Ubiquitin/ISG15-Conjugating Enzyme E2 L6 (UBE2L6) is an enzyme member of the E2 ubiquitin-conjugating enzyme family. UBE2L6 plays a same function as UBE2D; it catalyzes the covalent attachment of...

system_update_altDatasheetHuman OTUB2 Recombinant Protein Ubiquitin Thioesterase OTUB2 belongs to the peptidase C65 family, functions as a hydrolase that can remove conjugated ubiquitin from proteins in vitro, may plays an important regulatory role at...

system_update_altDatasheetHuman UCHL3/UCH-L3 Recombinant Protein Ubiquitin Carboxyl-Terminal Hydrolases (UCHs) are a family of cysteine hydrolases. They catalyze the hydrolysis of amides, thioesters and esters, peptide and isopeptide bonds formed by the...

system_update_altDatasheetHuman UCHL1/PGP9.5 Recombinant Protein Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 (UCHL1) belongs to the Peptidase C12 family. UCHL1 is specifically expressed in the neurons and in cells of the diffuse neuroendocrine...

system_update_altDatasheetHuman PITPNA Recombinant Protein Phosphatidylinositol Transfer Protein ? Isoform (PITPNA) is found in the cytoplasm and belongs to the PtdIns transfer protein family. PITPNA is a ubiquitous and highly conserved protein in...

system_update_altDatasheetHuman Ube2H Recombinant Protein Ubiquitin-Conjugating Enzyme E2 H (UBE2H) belongs to the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting...

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system_update_altDatasheetHuman UBE2D4 Recombinant Protein Ubiquitin-Conjugating Enzyme E2 D4 (UBE2D4) is a ligase that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2D4 has been proposed to participate in Ubl conjugation pathway. UBE2D4 takes...

system_update_altDatasheetHuman UBE2D1 Recombinant Protein Ubiquitin-conjugating enzyme E2 D1 (UBE2D1); a member of human E2 ubiquitin-conjugating enzymes; is closely related to SFT; which is short for stimulator of iron (Fe) transport. In other words;...

system_update_altDatasheetHuman ERP27 Recombinant Protein Endoplasmic reticulum resident protein 27; also known as ER protein 27; C12orf46 and ERP27; is an endoplasmic reticulum luminal protein which is a member of the protein disulfide isomerase family...

system_update_altDatasheetHuman Transthyretin/TTR Recombinant Protein Transthyretin is a secreted and cytoplasm protein which belongs to the Transthyretin family. Transthyretin is detected in serum and cerebrospinal fluid (at protein level). It is highly...

system_update_altDatasheetHuman Osteopontin/SPP1 Recombinant Protein Secreted Phosphoprotein 1 (SPP1) is a secreted multifunctional glycoprotein. Its putative functions include roles in bone metabolism, immune regulation, wound healing, cell survival,...

system_update_altDatasheetHuman PPT1 Recombinant Protein Palmitoyl-protein thioesterase 1(PPT-1 for short), also known as Palmitoyl-protein hydrolase 1, belongs to the palmitoyl-protein thioesterase family. It is a small glycoprotein involved in the...

system_update_altDatasheetHuman PMP2/FABP8 Recombinant Protein Myelin P2 Protein (PMP2) is a cytoplasmic protein which belongs to the Fatty-acid binding protein (FABP) family of calycin superfamily. PMP2 is a small, basic, and cytoplasmic lipid binding...

system_update_altDatasheetHuman Myoglobin/MB Recombinant Protein Myoglobin is a 17KDa cytoplasmic oxygen-binding protein encoded by the MB gene and expressed in myocytes of the heart and skeletal muscle. Its name derives from its structural and...

system_update_altDatasheetHuman Thyroid peroxidase/TPO Recombinant Protein Thyroid peroxidase is a membrane-bound glycoprotein which belongs to the peroxidase family, XPO subfamily. It contains 1 EGF-like domain and 1 Sushi (CCP/SCR) domain. Thyroid...

system_update_altDatasheetHuman NACHRA5/CHRNA5 Recombinant Protein Neuronal Acetylcholine Receptor Subunit ?-5 (NACHRA5) is a member of the ligand-gated ion channel family. Neuronal AChR is composed of two different type of subunits: ? and non-?. When...

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system_update_altDatasheetHuman UBE2D4 Recombinant Protein UBE2D4 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation;...

system_update_altDatasheetHuman CLIC3 Recombinant Protein Chloride intracellular channel protein 3 (CLIC3) is encoded by the CLIC3 gene. CLIC3 is a single-pass membrane protein which belongs to the chloride channel CLIC family. It contains one GST...

system_update_altDatasheetHuman HBAZ Recombinant Protein Hemoglobin Subunit Zeta (HBZ) is a member of the Globin family. The zeta chain is an alpha-type chain of mammalian embryonic Hemoglobin that is synthesized primarily in the yolk sac of the early...

system_update_altDatasheetHuman HBA1 Recombinant Protein Hemoglobin subunit alpha 1 (HBA1), also known as ?2β2, is a hetero-tetramer consisting of two ? and two β subunits held together by non-covalent interactions. Each subunit contains a heme...

system_update_altDatasheetHuman CLIC1 Recombinant Protein Chloride Intracellular Channel Protein 1 (CLIC1) belongs to the Chloride Channel CLIC family and contains one GST C-terminal domain. CLIC1 can be expressed in various cell types, but it is...

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system_update_altDatasheetHuman ERP27 Recombinant Protein ERP27 contains 1 thioredoxin domain and is a noncatalytic member of the protein disulfide isomerase family. Protein disulfide isomerases (PDIs) constitute a family of structurally related enzymes...

system_update_altDatasheetHuman CHRNB3 Recombinant Protein Neuronal acetylcholine receptor subunit beta-3(CHRNB3) is a cell membrane protein and belongs to the ligand-gated ion channel (TC 1.A.9) family. CHRNB3 seems to be composed of two different type...

system_update_altDatasheetHuman FABP4/A-FABP Recombinant Protein Fatty acid-binding protein; adipocyte; also known as Adipocyte-type fatty acid-binding protein; Fatty acid-binding protein 4; Adipocyte lipid-binding protein; and FABP4; is a cytoplasm...

system_update_altDatasheetHuman NEDD8 Recombinant Protein Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is...